{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(5)"],"submitter":["Zhang Y"],"pubmed_abstract":["MIcroglia/macrophage-mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral hemorrhage. Dynamic cytoskeletal changes accompany phagocytosis. However, whether and how these changes are associated with microglia/macrophage-mediated erythrophagocytosis remain unclear. In this study, we investigated the function of acetylated α-tubulin, a stabilized microtubule form, in microglia/macrophage erythrophagocytosis after intracerebral hemorrhage both in vitro and in vivo. We first assessed the function of acetylated α-tubulin in erythrophagocytosis using primary DiO GFP-labeled red blood cells co-cultured with the BV2 microglia or RAW264.7 macrophage cell lines. Acetylated α-tubulin expression was significantly decreased in BV2 and RAW264.7 cells during erythrop"],"journal":["Neural regeneration research"],"pagination":["1072-1077"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10749593"],"repository":["biostudies-literature"],"pubmed_title":["ATAT1 deficiency enhances microglia/macrophage-mediated erythrophagocytosis and hematoma absorption following intracerebral hemorrhage."],"pmcid":["PMC10749593"],"pubmed_authors":["Xu L","Cao M","Zhang Y","He X","Chen Y","Huang P","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"ATAT1 deficiency enhances microglia/macrophage-mediated erythrophagocytosis and hematoma absorption following intracerebral hemorrhage.","description":"MIcroglia/macrophage-mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral hemorrhage. Dynamic cytoskeletal changes accompany phagocytosis. However, whether and how these changes are associated with microglia/macrophage-mediated erythrophagocytosis remain unclear. In this study, we investigated the function of acetylated α-tubulin, a stabilized microtubule form, in microglia/macrophage erythrophagocytosis after intracerebral hemorrhage both in vitro and in vivo. We first assessed the function of acetylated α-tubulin in erythrophagocytosis using primary DiO GFP-labeled red blood cells co-cultured with the BV2 microglia or RAW264.7 macrophage cell lines. Acetylated α-tubulin expression was significantly decreased in BV2 and RAW264.7 cells during erythrop","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-08T15:14:34.833Z","creation":"2025-04-04T19:00:58.029Z"},"accession":"S-EPMC10749593","cross_references":{"pubmed":["37862210"],"doi":["10.4103/1673-5374.382984"]}}