biostudies-literatureUnknown3(6)Yang S<h4>Background</h4>Coronary pressure- and flow-derived parameters have prognostic value.<h4>Objectives</h4>This study aims to investigate the individual and combined prognostic relevance of pressure and flow parameters reflecting resting and hyperemic conditions.<h4>Methods</h4>A total of 1,971 vessels deferred from revascularization after invasive pressure and flow assessment were included from the international multicenter registry. Abnormal resting pressure and flow were defined as distal coronary pressure/aortic pressure ≤0.92 and high resting flow (1/resting mean transit time >2.4 or resting average peak flow >22.7 cm/s), and abnormal hyperemic pressure and flow as fractional flow reserve ≤0.80 and low hyperemic flow (1/hyperemic mean transit time <2.2 or hyperemic average peak flow <JACC. Asia865-877https://www.ebi.ac.uk/biostudies/studies/S-EPMC10751649biostudies-literaturePrognostic Implications of Individual and Combinations of Resting and Hyperemic Coronary Pressure and Flow Parameters.PMC10751649Matsuo HAppelman YNiccoli GJung JHCambero MMWoudstra JChristiansen EHKoo BKBoerhout CKMvan de Hoef TPTanaka NLee JMHoshino MMarques Kvan Royen NMurai TPiek JJPinto MENakayama MVink CEMMeuwissen MBanerjee RKim HKShin ESLee SHChamuleau SAJde Waard GAKnaapen PEscaned JKakuta THwang DDoh JHEftekhari ANam CWRenteria HMEffat MAYang SBeijk MAMfalsePrognostic Implications of Individual and Combinations of Resting and Hyperemic Coronary Pressure and Flow Parameters.<h4>Background</h4>Coronary pressure- and flow-derived parameters have prognostic value.<h4>Objectives</h4>This study aims to investigate the individual and combined prognostic relevance of pressure and flow parameters reflecting resting and hyperemic conditions.<h4>Methods</h4>A total of 1,971 vessels deferred from revascularization after invasive pressure and flow assessment were included from the international multicenter registry. Abnormal resting pressure and flow were defined as distal coronary pressure/aortic pressure ≤0.92 and high resting flow (1/resting mean transit time >2.4 or resting average peak flow >22.7 cm/s), and abnormal hyperemic pressure and flow as fractional flow reserve ≤0.80 and low hyperemic flow (1/hyperemic mean transit time <2.2 or hyperemic average peak flow <2023-01-01T00:00:00Z2023 Dec2026-05-28T13:05:00.118Z2025-04-06T16:27:35.915ZS-EPMC107516493815579710.1016/j.jacasi.2023.07.009