{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["100(1)"],"submitter":["Yang Q"],"pubmed_abstract":["<h4>Objective</h4>To investigate the diagnostic efficacy of serum IL-33 single indicator and combined indicators for asthma in children.<h4>Methods</h4>132 children were initially diagnosed with asthma during acute exacerbation and 100 healthy children were included. Serum IL-33 concentration differences were compared between asthmatic and normal children. Correlations between IL-33 with pulmonary function parameters, FeNO, peripheral blood EOS counts and serum total IgE were analyzed in asthmatic children. ROC curves were used to assess IL-33 diagnostic efficacy and its combined indicators. To prevent overfitting of the predictive model, the hold-out cross-validation method was used.<h4>Results</h4>(1) Serum IL-33 concentrations were significantly higher in children with asthma than in no"],"journal":["Jornal de pediatria"],"pagination":["81-87"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10751693"],"repository":["biostudies-literature"],"pubmed_title":["Serum interleukin-33 combined with FEF75% z-score and FeNO improves the diagnostic accuracy of asthma in children."],"pmcid":["PMC10751693"],"pubmed_authors":["Zheng Y","Li S","Zhang Y","Dong J","Xu Q","Li A","Yang Q","Xiong X"],"additional_accession":[]},"is_claimable":false,"name":"Serum interleukin-33 combined with FEF75% z-score and FeNO improves the diagnostic accuracy of asthma in children.","description":"<h4>Objective</h4>To investigate the diagnostic efficacy of serum IL-33 single indicator and combined indicators for asthma in children.<h4>Methods</h4>132 children were initially diagnosed with asthma during acute exacerbation and 100 healthy children were included. Serum IL-33 concentration differences were compared between asthmatic and normal children. Correlations between IL-33 with pulmonary function parameters, FeNO, peripheral blood EOS counts and serum total IgE were analyzed in asthmatic children. ROC curves were used to assess IL-33 diagnostic efficacy and its combined indicators. To prevent overfitting of the predictive model, the hold-out cross-validation method was used.<h4>Results</h4>(1) Serum IL-33 concentrations were significantly higher in children with asthma than in no","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan-Feb","modification":"2026-05-29T02:13:25.906Z","creation":"2025-04-04T10:30:04.436Z"},"accession":"S-EPMC10751693","cross_references":{"pubmed":["37741632"],"doi":["10.1016/j.jped.2023.08.004"]}}