biostudies-literatureUnknown100(1)Yang Q<h4>Objective</h4>To investigate the diagnostic efficacy of serum IL-33 single indicator and combined indicators for asthma in children.<h4>Methods</h4>132 children were initially diagnosed with asthma during acute exacerbation and 100 healthy children were included. Serum IL-33 concentration differences were compared between asthmatic and normal children. Correlations between IL-33 with pulmonary function parameters, FeNO, peripheral blood EOS counts and serum total IgE were analyzed in asthmatic children. ROC curves were used to assess IL-33 diagnostic efficacy and its combined indicators. To prevent overfitting of the predictive model, the hold-out cross-validation method was used.<h4>Results</h4>(1) Serum IL-33 concentrations were significantly higher in children with asthma than in noJornal de pediatria81-87https://www.ebi.ac.uk/biostudies/studies/S-EPMC10751693biostudies-literatureSerum interleukin-33 combined with FEF75% z-score and FeNO improves the diagnostic accuracy of asthma in children.PMC10751693Zheng YLi SZhang YDong JXu QLi AYang QXiong XfalseSerum interleukin-33 combined with FEF75% z-score and FeNO improves the diagnostic accuracy of asthma in children.<h4>Objective</h4>To investigate the diagnostic efficacy of serum IL-33 single indicator and combined indicators for asthma in children.<h4>Methods</h4>132 children were initially diagnosed with asthma during acute exacerbation and 100 healthy children were included. Serum IL-33 concentration differences were compared between asthmatic and normal children. Correlations between IL-33 with pulmonary function parameters, FeNO, peripheral blood EOS counts and serum total IgE were analyzed in asthmatic children. ROC curves were used to assess IL-33 diagnostic efficacy and its combined indicators. To prevent overfitting of the predictive model, the hold-out cross-validation method was used.<h4>Results</h4>(1) Serum IL-33 concentrations were significantly higher in children with asthma than in no2024-01-01T00:00:00Z2024 Jan-Feb2026-05-29T02:13:25.906Z2025-04-04T10:30:04.436ZS-EPMC107516933774163210.1016/j.jped.2023.08.004