{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(12)"],"submitter":["Li G"],"pubmed_abstract":["The rate constants <i>k</i><sub>H</sub> (<i>k</i><sub>D</sub>) have been determined at 27 °C for H· (D·) transfer from CpCr(CO)<sub>3</sub>H(D) to the C=C bonds of various enamides. This process leads to the formation of α-amino radicals. Vinyl enamides with <i>N</i>-alkyl and <i>N</i>-phenyl substituents have proven to be good H· acceptors, with rate constants close to those of styrene and methyl methacrylate. A methyl substituent on the incipient radical site decreases <i>k</i><sub>H</sub> by a factor of 4; a methyl substituent on the carbon that will receive the H· decreases <i>k</i><sub>H</sub> by a factor of 380. The measured <i>k</i><sub>H</sub> values indicate that these α-amino radicals can be used for the cyclization of enamides to pyrrolidines. A vanadium hydride, HV(CO)<sub>4</s"],"journal":["JACS Au"],"pagination":["3366-3373"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10751771"],"repository":["biostudies-literature"],"pubmed_title":["Kinetics of H· Transfer from CpCr(CO)<sub>3</sub>H to Various Enamides: Application to Construction of Pyrrolidines."],"pmcid":["PMC10751771"],"pubmed_authors":["Li G","Qian J","Hong X","Shi S","Norton JR","Xu GX","Liu JR"],"additional_accession":[]},"is_claimable":false,"name":"Kinetics of H· Transfer from CpCr(CO)<sub>3</sub>H to Various Enamides: Application to Construction of Pyrrolidines.","description":"The rate constants <i>k</i><sub>H</sub> (<i>k</i><sub>D</sub>) have been determined at 27 °C for H· (D·) transfer from CpCr(CO)<sub>3</sub>H(D) to the C=C bonds of various enamides. This process leads to the formation of α-amino radicals. Vinyl enamides with <i>N</i>-alkyl and <i>N</i>-phenyl substituents have proven to be good H· acceptors, with rate constants close to those of styrene and methyl methacrylate. A methyl substituent on the incipient radical site decreases <i>k</i><sub>H</sub> by a factor of 4; a methyl substituent on the carbon that will receive the H· decreases <i>k</i><sub>H</sub> by a factor of 380. The measured <i>k</i><sub>H</sub> values indicate that these α-amino radicals can be used for the cyclization of enamides to pyrrolidines. A vanadium hydride, HV(CO)<sub>4</s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-21T15:06:06.686Z","creation":"2025-04-21T15:06:06.686Z"},"accession":"S-EPMC10751771","cross_references":{"pubmed":["38155656"],"doi":["10.1021/jacsau.3c00529"]}}