{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hamshaw I"],"funding":["Wellcome Trust"],"pagination":["1285779"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10752971"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["Preterm birth is the leading cause of infant morbidity and mortality. There has been an interest in developing prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>) antagonists as a new treatment for preterm birth, although much of the rationale for their use is based on studies in rodents where PGF<sub>2α</sub> initiates labour by regressing the corpus luteum and reducing systemic progesterone concentrations. How PGF<sub>2α</sub> antagonism would act in humans who do not have a fall in systemic progesterone remains unclear. One possibility, in addition to an acute stimulation of contractions, is a direct alteration of the myometrial smooth muscle cell state towards a pro-labour phenotype. In this study, we developed an immortalised myometrial cell line, MYLA, derived from myometrial tissue obta"],"journal":["Frontiers in pharmacology"],"pubmed_title":["PGF<sub>2α</sub> induces a pro-labour phenotypical switch in human myometrial cells that can be inhibited with PGF<sub>2α</sub> receptor antagonists."],"pmcid":["PMC10752971"],"funding_grant_id":["200870/Z/16/Z"],"pubmed_authors":["Blanks AM","Hamshaw I","Baxter L","Wever WJ","Pinton P","Ferguson GD","Stark R","Alam MT","Straube A","Sen A","Yue Y","Yin J"],"additional_accession":[]},"is_claimable":false,"name":"PGF<sub>2α</sub> induces a pro-labour phenotypical switch in human myometrial cells that can be inhibited with PGF<sub>2α</sub> receptor antagonists.","description":"Preterm birth is the leading cause of infant morbidity and mortality. There has been an interest in developing prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>) antagonists as a new treatment for preterm birth, although much of the rationale for their use is based on studies in rodents where PGF<sub>2α</sub> initiates labour by regressing the corpus luteum and reducing systemic progesterone concentrations. How PGF<sub>2α</sub> antagonism would act in humans who do not have a fall in systemic progesterone remains unclear. One possibility, in addition to an acute stimulation of contractions, is a direct alteration of the myometrial smooth muscle cell state towards a pro-labour phenotype. In this study, we developed an immortalised myometrial cell line, MYLA, derived from myometrial tissue obta","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-20T09:26:35.587Z","creation":"2025-04-20T09:26:35.587Z"},"accession":"S-EPMC10752971","cross_references":{"pubmed":["38155905"],"doi":["10.3389/fphar.2023.1285779"]}}