{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(51)"],"submitter":["De Tran Q"],"pubmed_abstract":["The Zika virus (ZIKV) is believed to cause birth defects, and no anti-ZIKV drugs have been approved by medical organizations to date. Starting from antimicrobial lead compounds with a pyrazolo[3,4-<i>d</i>]pyridazine-7-one scaffold, we synthesized 16 derivatives and screened their ability to interfere with ZIKV infection utilizing a cell-based phenotypic assay. Of these, five compounds showed significant inhibition of ZIKV with a selective index value greater than 4.6. In particular, compound <b>9b</b> showed the best anti-ZIKV activity with a selectivity index of 22.4 (half-maximal effective concentration = 25.6 μM and 50% cytotoxic concentration = 572.4 μM). Through the brine shrimp lethality bioassay, <b>9b</b>, <b>10b</b>, <b>12</b>, <b>17a</b>, and <b>19a</b> showed median lethal dose"],"journal":["ACS omega"],"pagination":["48994-49008"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10753549"],"repository":["biostudies-literature"],"pubmed_title":["ZIKV Inhibitors Based on Pyrazolo[3,4-<i>d</i>]pyridazine-7-one Core: Rational Design, <i>In Vitro</i> Evaluation, and Theoretical Studies."],"pmcid":["PMC10753549"],"pubmed_authors":["Nguyen CQ","Bich Hau VT","Minh Nguyen TH","Tuan NT","Quan PM","Chau Thanh NQ","Binh TD","Nguyen HP","Men TT","Cam TT","De Tran Q","Dang QL","Thi Le MU","Tuan ND","Thu Thuy NT","Buu Hue BT"],"additional_accession":[]},"is_claimable":false,"name":"ZIKV Inhibitors Based on Pyrazolo[3,4-<i>d</i>]pyridazine-7-one Core: Rational Design, <i>In Vitro</i> Evaluation, and Theoretical Studies.","description":"The Zika virus (ZIKV) is believed to cause birth defects, and no anti-ZIKV drugs have been approved by medical organizations to date. Starting from antimicrobial lead compounds with a pyrazolo[3,4-<i>d</i>]pyridazine-7-one scaffold, we synthesized 16 derivatives and screened their ability to interfere with ZIKV infection utilizing a cell-based phenotypic assay. Of these, five compounds showed significant inhibition of ZIKV with a selective index value greater than 4.6. In particular, compound <b>9b</b> showed the best anti-ZIKV activity with a selectivity index of 22.4 (half-maximal effective concentration = 25.6 μM and 50% cytotoxic concentration = 572.4 μM). Through the brine shrimp lethality bioassay, <b>9b</b>, <b>10b</b>, <b>12</b>, <b>17a</b>, and <b>19a</b> showed median lethal dose","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-05-29T02:51:44.645Z","creation":"2024-12-04T01:28:09.615Z"},"accession":"S-EPMC10753549","cross_references":{"pubmed":["38162759"],"doi":["10.1021/acsomega.3c06612"]}}