{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li YQ"],"funding":["Guangdong Innovative and Entrepreneurial Research Team Program","Chang Jiang Scholars Program","Tanoto Foundation","National Natural Science Foundation of China","Singapore Ministry of Health's National Medical Research Council","Sci-Tech Project Foundation of Guangzhou City","Ling Foundation","New Century International Pte Ltd"],"pagination":["e2303913"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10754138"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(36)"],"pubmed_abstract":["Extranodal natural killer/T-cell lymphoma (NKTCL) is an aggressive type of lymphoma associated with Epstein-Barr virus (EBV) and characterized by heterogeneous tumor behaviors. To better understand the origins of the heterogeneity, this study utilizes single-cell RNA sequencing (scRNA-seq) analysis to profile the tumor microenvironment (TME) of NKTCL at the single-cell level. Together with in vitro and in vivo models, the study identifies a subset of LMP1<sup>+</sup> malignant NK cells contributing to the tumorigenesis and development of heterogeneous malignant cells in NKTCL. Furthermore, malignant NK cells interact with various immunocytes via chemokines and their receptors, secrete substantial DPP4 that impairs the chemotaxis of immunocytes and regulates their infiltration. They also ex"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Single-Cell Analysis Reveals Malignant Cells Reshape the Cellular Landscape and Foster an Immunosuppressive Microenvironment of Extranodal NK/T-Cell Lymphoma."],"pmcid":["PMC10754138"],"funding_grant_id":["82130078","2016ZT06S638","201707020039","82261160657","NMRC-OFLCG-18May0028"],"pubmed_authors":["Xiong J","Huang D","Peng RJ","Zhao WL","Ong CK","Liu Y","Yan WX","Lin GW","Bei JX","Ling YH","Zhang YT","Wang XX","Lim JQ","Hussein IN","Xia Y","Li YQ","Huang HQ","Cui Q","Wei PP","He S","Huang Y","Luo CL","Gao Y","Jiang JX","Lim ST","Ma D","Cheng CL","Chan JY"],"additional_accession":[]},"is_claimable":false,"name":"Single-Cell Analysis Reveals Malignant Cells Reshape the Cellular Landscape and Foster an Immunosuppressive Microenvironment of Extranodal NK/T-Cell Lymphoma.","description":"Extranodal natural killer/T-cell lymphoma (NKTCL) is an aggressive type of lymphoma associated with Epstein-Barr virus (EBV) and characterized by heterogeneous tumor behaviors. To better understand the origins of the heterogeneity, this study utilizes single-cell RNA sequencing (scRNA-seq) analysis to profile the tumor microenvironment (TME) of NKTCL at the single-cell level. Together with in vitro and in vivo models, the study identifies a subset of LMP1<sup>+</sup> malignant NK cells contributing to the tumorigenesis and development of heterogeneous malignant cells in NKTCL. Furthermore, malignant NK cells interact with various immunocytes via chemokines and their receptors, secrete substantial DPP4 that impairs the chemotaxis of immunocytes and regulates their infiltration. They also ex","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-06-03T13:05:20.488Z","creation":"2025-04-06T19:20:13.848Z"},"accession":"S-EPMC10754138","cross_references":{"pubmed":["37949673"],"doi":["10.1002/advs.202303913"]}}