biostudies-literatureUnknown4(1)Rueb MThe majority of traumatic encephalopathy syndrome (TES) cases have been reported in former contact sport athletes. This is the first case with TES in a 19-year-old male patient with progressive cognitive decline after daily domestic physical violence through repeated hits to the head for 15 years. The patient presented with a moderate depressive episode and progressive cognitive decline. Tau positron emission tomography (PET) with 220 MBq of [¹⁸F]PI-2620 revealed increased focal signal at the frontal and parietal white/gray matter border. Brain magnetic resonance imaging (MRI) showed a cavum septum pellucidum, reduced left-sided hippocampal volume, and a left midbrain lesion. Cerebrospinal fluid results showed elevated total and p-tau. Neurocognitive testing at admission showed Neurotrauma reports857-862https://www.ebi.ac.uk/biostudies/studies/S-EPMC10754342biostudies-literatureTraumatic Encephalopathy Syndrome and Tauopathy in a 19-Year-Old With Child Abuse.PMC10754342Rueb MGersing ASimren JAdorjan KBrendel MZetterberg HKoerte IKRauen KfalseTraumatic Encephalopathy Syndrome and Tauopathy in a 19-Year-Old With Child Abuse.The majority of traumatic encephalopathy syndrome (TES) cases have been reported in former contact sport athletes. This is the first case with TES in a 19-year-old male patient with progressive cognitive decline after daily domestic physical violence through repeated hits to the head for 15 years. The patient presented with a moderate depressive episode and progressive cognitive decline. Tau positron emission tomography (PET) with 220 MBq of [¹⁸F]PI-2620 revealed increased focal signal at the frontal and parietal white/gray matter border. Brain magnetic resonance imaging (MRI) showed a cavum septum pellucidum, reduced left-sided hippocampal volume, and a left midbrain lesion. Cerebrospinal fluid results showed elevated total and p-tau. Neurocognitive testing at admission showed 2023-01-01T00:00:00Z20232025-04-19T14:30:34.024Z2025-04-19T14:30:34.024ZS-EPMC107543423815607410.1089/neur.2023.0078