{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harriott NC"],"funding":["Hastings Foundation","NIDDK NIH HHS","University of South Carolina","USC Keck School of Medicine"],"pagination":["e23320"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10755324"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["SARS-CoV-2 infection remains a major public health concern, particularly for the aged and those individuals with co-morbidities at risk for developing severe COVID-19. Understanding the pathogenesis and biomarkers associated with responses to SARS-CoV-2 infection remain critical components in developing effective therapeutic approaches, especially in cases of severe and long-COVID-19. In this study blood plasma protein expression was compared in subjects with mild, moderate, and severe COVID-19 disease. Evaluation of an inflammatory protein panel confirms upregulation of proteins including TNFβ, IL-6, IL-8, IL-12, already associated with severe cytokine storm and progression to severe COVID-19. Importantly, we identify several proteins not yet associated with COVID-19 disease, including me"],"journal":["Heliyon"],"pubmed_title":["Proteomic profiling identifies biomarkers of COVID-19 severity."],"pmcid":["PMC10755324"],"funding_grant_id":["P30 DK054759"],"pubmed_authors":["Harriott NC","Ryan AL"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic profiling identifies biomarkers of COVID-19 severity.","description":"SARS-CoV-2 infection remains a major public health concern, particularly for the aged and those individuals with co-morbidities at risk for developing severe COVID-19. Understanding the pathogenesis and biomarkers associated with responses to SARS-CoV-2 infection remain critical components in developing effective therapeutic approaches, especially in cases of severe and long-COVID-19. In this study blood plasma protein expression was compared in subjects with mild, moderate, and severe COVID-19 disease. Evaluation of an inflammatory protein panel confirms upregulation of proteins including TNFβ, IL-6, IL-8, IL-12, already associated with severe cytokine storm and progression to severe COVID-19. Importantly, we identify several proteins not yet associated with COVID-19 disease, including me","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-07-15T13:59:59.267Z","creation":"2025-04-04T03:20:37.114Z"},"accession":"S-EPMC10755324","cross_references":{"pubmed":["38163173"],"doi":["10.1016/j.heliyon.2023.e23320"]}}