biostudies-literatureHarriott NCHastings FoundationNIDDK NIH HHSUniversity of South CarolinaUSC Keck School of Medicinee23320https://www.ebi.ac.uk/biostudies/studies/S-EPMC10755324biostudies-literatureUnknown10(1)SARS-CoV-2 infection remains a major public health concern, particularly for the aged and those individuals with co-morbidities at risk for developing severe COVID-19. Understanding the pathogenesis and biomarkers associated with responses to SARS-CoV-2 infection remain critical components in developing effective therapeutic approaches, especially in cases of severe and long-COVID-19. In this study blood plasma protein expression was compared in subjects with mild, moderate, and severe COVID-19 disease. Evaluation of an inflammatory protein panel confirms upregulation of proteins including TNFβ, IL-6, IL-8, IL-12, already associated with severe cytokine storm and progression to severe COVID-19. Importantly, we identify several proteins not yet associated with COVID-19 disease, including meHeliyonProteomic profiling identifies biomarkers of COVID-19 severity.PMC10755324P30 DK054759Harriott NCRyan ALfalseProteomic profiling identifies biomarkers of COVID-19 severity.SARS-CoV-2 infection remains a major public health concern, particularly for the aged and those individuals with co-morbidities at risk for developing severe COVID-19. Understanding the pathogenesis and biomarkers associated with responses to SARS-CoV-2 infection remain critical components in developing effective therapeutic approaches, especially in cases of severe and long-COVID-19. In this study blood plasma protein expression was compared in subjects with mild, moderate, and severe COVID-19 disease. Evaluation of an inflammatory protein panel confirms upregulation of proteins including TNFβ, IL-6, IL-8, IL-12, already associated with severe cytokine storm and progression to severe COVID-19. Importantly, we identify several proteins not yet associated with COVID-19 disease, including me2024-01-01T00:00:00Z2024 Jan2026-07-15T13:59:59.267Z2025-04-04T03:20:37.114ZS-EPMC107553243816317310.1016/j.heliyon.2023.e23320