{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(1)"],"submitter":["Perkins DW"],"funding":["Breast Cancer Now"],"pubmed_abstract":["Disseminated tumor cells frequently exhibit a period of dormancy, rendering them chemotherapy insensitive; conversely, the systemic delivery of chemotherapies can result in normal tissue damage. Using multiple mouse and human breast cancer models, we demonstrate that prior chemotherapy administration enhances metastatic colonization and outgrowth. <i>In vitro</i>, chemotherapy-treated fibroblasts display a pro-tumorigenic senescence-associated secretory phenotype (SASP) and are effectively eliminated by targeting the anti-apoptotic protein BCL-xL. <i>In vivo</i>, chemotherapy treatment induces SASP expression in normal tissues; however, the accumulation of senescent cells is limited, and BCL-xL inhibitors are unable to reduce chemotherapy-enhanced metastasis. This likely reflects that chem"],"journal":["iScience"],"pagination":["108503"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10755366"],"repository":["biostudies-literature"],"pubmed_title":["Therapy-induced normal tissue damage promotes breast cancer metastasis."],"pmcid":["PMC10755366"],"pubmed_authors":["Perkins DW","Buus R","Steiner I","Robertson D","O'Leary L","Haider S","Isacke CM"],"additional_accession":[]},"is_claimable":false,"name":"Therapy-induced normal tissue damage promotes breast cancer metastasis.","description":"Disseminated tumor cells frequently exhibit a period of dormancy, rendering them chemotherapy insensitive; conversely, the systemic delivery of chemotherapies can result in normal tissue damage. Using multiple mouse and human breast cancer models, we demonstrate that prior chemotherapy administration enhances metastatic colonization and outgrowth. <i>In vitro</i>, chemotherapy-treated fibroblasts display a pro-tumorigenic senescence-associated secretory phenotype (SASP) and are effectively eliminated by targeting the anti-apoptotic protein BCL-xL. <i>In vivo</i>, chemotherapy treatment induces SASP expression in normal tissues; however, the accumulation of senescent cells is limited, and BCL-xL inhibitors are unable to reduce chemotherapy-enhanced metastasis. This likely reflects that chem","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-05-28T20:08:29.044Z","creation":"2025-04-04T03:20:43.124Z"},"accession":"S-EPMC10755366","cross_references":{"pubmed":["38161426"],"doi":["10.1016/j.isci.2023.108503"]}}