biostudies-literatureKhan MDeanship of Scientific Research, King Khalid Universitye23323https://www.ebi.ac.uk/biostudies/studies/S-EPMC10757017biostudies-literatureUnknown10(1)Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic individuals. <i>Bis</i>(dimethylamino)benzophenone derivatives <b>1</b>-<b>27</b> were synthesized from <i>bis</i>(dimethylamino)benzophenone via two-step reaction. Different spectroscopic techniques, including EI-MS and 1H NMR, were employed to characterize all synthetic derivatives. The elemental composition of synthetic compounds was confirmed by elemental analysis and results were found in agreement with the calculated values. The synthetic compounds <b>1</b>-<b>27</b> were evaluated for <i>α</i>-glucosidase inhibitory activity, except five compounds all derivatives showed good to moderate inhibitory potential in the range of IC₅₀ = 0.28 ± 2.65 - 0.94 ± 2.20 μM. Among them, the most actHeliyonSynthesis of new <i>bis</i>(dimethylamino)benzophenone hydrazone for diabetic management: <i>In-vitro</i> and <i>in-silico</i> approach.PMC107570172/100/44Ahad GKhan AKanwalKhan KMUddin JSalar UAl-Harrasi AAlam APerveen SUllah SAjmal AKhan MWadood AfalseSynthesis of new <i>bis</i>(dimethylamino)benzophenone hydrazone for diabetic management: <i>In-vitro</i> and <i>in-silico</i> approach.Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic individuals. <i>Bis</i>(dimethylamino)benzophenone derivatives <b>1</b>-<b>27</b> were synthesized from <i>bis</i>(dimethylamino)benzophenone via two-step reaction. Different spectroscopic techniques, including EI-MS and 1H NMR, were employed to characterize all synthetic derivatives. The elemental composition of synthetic compounds was confirmed by elemental analysis and results were found in agreement with the calculated values. The synthetic compounds <b>1</b>-<b>27</b> were evaluated for <i>α</i>-glucosidase inhibitory activity, except five compounds all derivatives showed good to moderate inhibitory potential in the range of IC₅₀ = 0.28 ± 2.65 - 0.94 ± 2.20 μM. Among them, the most act2024-01-01T00:00:00Z2024 Jan2026-05-29T02:10:41.79Z2025-02-18T23:26:18.02ZS-EPMC107570173816311210.1016/j.heliyon.2023.e23323