{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kahl A"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["94-105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10757264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23"],"pubmed_abstract":["Fasciola hepatica infections lead to severe health problems and production losses in sheep farming, if not treated effectively. Triclabendazole has been used extensively over decades due to its unique efficacy range against all definitive hostfluke stages but published data about the susceptibility of F. hepatica to anthelmintics in Germany are lacking. This study aimed to identify current F. hepatica infections in German sheep flocks by coproscopic examinations and to evaluate the efficacy of anthelmintics with a focus on triclabendazole in a field study conducted from 2020 to 2022. Initial screening included 71 sheep farms, many of them with known history of fasciolosis. In this highly biased sample set, the frequency of F. hepatica infection at individual sheep and farm level were 12.8%"],"journal":["International journal for parasitology. Drugs and drug resistance"],"pubmed_title":["Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms."],"pmcid":["PMC10757264"],"funding_grant_id":["BB/P001912/1"],"pubmed_authors":["Weiher W","Terhalle W","Hodgkinson J","Krucken J","Kahl A","Steuber S","von Samson-Himmelstjerna G","Williams D","Ganter M","Helm C"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms.","description":"Fasciola hepatica infections lead to severe health problems and production losses in sheep farming, if not treated effectively. Triclabendazole has been used extensively over decades due to its unique efficacy range against all definitive hostfluke stages but published data about the susceptibility of F. hepatica to anthelmintics in Germany are lacking. This study aimed to identify current F. hepatica infections in German sheep flocks by coproscopic examinations and to evaluate the efficacy of anthelmintics with a focus on triclabendazole in a field study conducted from 2020 to 2022. Initial screening included 71 sheep farms, many of them with known history of fasciolosis. In this highly biased sample set, the frequency of F. hepatica infection at individual sheep and farm level were 12.8%","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-08-24T03:08:10.843Z","creation":"2025-04-19T14:33:03.508Z"},"accession":"S-EPMC10757264","cross_references":{"pubmed":["38006779"],"doi":["10.1016/j.ijpddr.2023.11.001"]}}