{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Solst SR"],"funding":["NIEHS NIH HHS","NCI NIH HHS"],"pagination":["456-461"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10759934"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["200(5)"],"pubmed_abstract":["Diffuse intrinsic pontine gliomas (DIPG) are an aggressive type of pediatric brain tumor with a very high mortality rate. Surgery has a limited role given the tumor's location. Palliative radiation therapy alleviates symptoms and prolongs survival, but median survival remains less than 1 year. There is no clear role for chemotherapy in DIPGs as trials adding chemotherapy to palliative radiation therapy have failed to improve survival compared to radiation alone. Thus, there is a critical need to identify tissue-specific radiosensitizers to improve clinical outcomes for patients with DIPGs. Pharmacologic (high dose) ascorbate (P-AscH-) is a promising anticancer therapy that sensitizes human tumors, including adult high-grade gliomas, to radiation by acting selectively as a generator of hydr"],"journal":["Radiation research"],"pubmed_title":["Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate."],"pmcid":["PMC10759934"],"funding_grant_id":["P30 ES005605","P30 CA086862","P01 CA217797"],"pubmed_authors":["Current K","Allen BG","Mapuskar KA","Solst SR","Howard ME","Graham CH","King SA","Caster JM","Rheem R","Spitz DR"],"additional_accession":[]},"is_claimable":false,"name":"Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate.","description":"Diffuse intrinsic pontine gliomas (DIPG) are an aggressive type of pediatric brain tumor with a very high mortality rate. Surgery has a limited role given the tumor's location. Palliative radiation therapy alleviates symptoms and prolongs survival, but median survival remains less than 1 year. There is no clear role for chemotherapy in DIPGs as trials adding chemotherapy to palliative radiation therapy have failed to improve survival compared to radiation alone. Thus, there is a critical need to identify tissue-specific radiosensitizers to improve clinical outcomes for patients with DIPGs. Pharmacologic (high dose) ascorbate (P-AscH-) is a promising anticancer therapy that sensitizes human tumors, including adult high-grade gliomas, to radiation by acting selectively as a generator of hydr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T01:59:42.096Z","creation":"2025-04-04T01:59:42.096Z"},"accession":"S-EPMC10759934","cross_references":{"pubmed":["37758035"],"doi":["10.1667/rade-23-00006.1","10.1667/RADE-23-00006.1"]}}