biostudies-literatureUnknown7(1)Benali F<h4>Importance</h4>Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age is associated with preexisting burdens of brain changes, visible on neuroimaging but rarely considered in acute decision-making or trials, is unknown.<h4>Objectives</h4>To explore the mediation of age on functional outcome by neuroimaging markers of frailty (hereinafter neuroimaging frailty) in patients with acute ischemic stroke receiving endovascular thrombectomy (EVT).<h4>Design, setting, and participants</h4>This cohort study was a post hoc analysis of the Safety and Efficacy of Nerinetide (NA-1) in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1) randomized clinical trial, which investigated intravenous (IV) nerinetide in patients who underwent JAMA network opene2349628https://www.ebi.ac.uk/biostudies/studies/S-EPMC10762575biostudies-literatureMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke.PMC10762575Hoppe JPallesen LPMaclean GBoulos MIKaminsky IACoutts SBEl-Jamal SMiller MGBrekenfeld COsteraas NLapierre MDanenbergs BDonnan GAStarkman SFilipowski GThornton JO'Hare AYaher NYDickerson LNg FCSchraeder NLMoreira TGzesh DAngle MWalker SAbramyuk ABester MRamirez LBrierley RELiddy AMSmith EEAlmqvist HMitchell PJEesa MBeauchamp BDyer EEHopyan JJDeegan CWilson DCShawawrah MAKNystrom KVWinzer SKenney CWong CHong JHPonting KRoss JEatman JDBarlinn KFridman SChiu RWong JSchwarz MDiCrescento SArsenault JNichols JAxelsson MCDrew RMilot GKlein GKlein BMcDougall CGOrgass HSchaad ELamers SPerera KSSharma LKAndersen LSaleem YAppelbohm HPaul JMuller NSalmon KJickling GCatanese LLesiuk HLopes KNBaxendell LAgarwal TCullen ACranefield JKoch FD'Souza AMcFarland MTurkel-Parrella DDeschaintre YVan Gaal SCLee JSEbreo NNg JLHwang DYLeary MABenali FOczkowski WJLee JJMurray KKenmuir CWells BChen STse DMai LMYao JZCayley AKelly CEHache AArcot KChen MNayar SChen CSharma MBoyle KJoyce TARohr AEriksson EHaas RAMorrish WNye JLRingleb PAStapf CVandervelde CSchmidt MHSiddiqui MMuller JCrandall SCShamy MSchonfeld MMattai AMPetersen NTeleg ELloret MSyed NMGerber JCGanesh AGioia LCKostyrko PLiu ZQuinn KABelagaje SBrennan RPSarma DMundiyanapurath SMurphy SMoussaddy AGariepy JLDos Santos ALarge MSmyth GKnowles BMEmmady PTelischak NWasyliw SJolteus JAnderson ABianchi NBudzik RFJeerakathil TPilgram-Pastor SScher EBrehm AYoo JLai SSouthwell ADemir NCRai VBarbret ZCuddy SHeyse MWalters RShen HGordon PShah KHwang IGJayaraman MVTauro SAhmed NConrad WAHunter GSaqqur MGaines NDMatouk CCHuynh TTong DDeb-Chatterji MMandzia JLDoppelheuer SESCAPE-NA1 InvestigatorsSpears JGlichrist VIbrahim AJeong KDewar BBaldwin JAbbott TCCaganap SDHaw CSOspel JMHeidenreich JOBurns PAJong LTLudwig BJSwartz RHRocha MKelly DFBae HFarb RMagnussen CFairall PSjostrand CWahlgren NCole EOliva CWilson LKDesai SMcElroy SCelik EKashani NHalbert KJun GEThirunavukkarasu SStretz HCKaiser DTalley TCFarkas JSchaafsma JFeineigle PBalabanski ARha JHWilliams SAVandorpe RWatkins CCGladstone DJHolloway WTymianski MBussinger PAPema PJLim YJSchlemm ECouillard PStewart TMaraj NStrecha ERoels CKaskar OBKleinig TJBullrich MBSummers DVTeitelbaum GPNg KHRoberts GGao BJacquin GFrankel MCampbell BCVSheth KNGoyal MSingh JJasak SDSiepmann TSingh NSingh RFasbinder BKSnead JMKim KHMurphy CBCoppola AMMacDonald DLinnell GSave SAlsultan ASBlackstock DKeselman BPuri ASHill MDShan DGBarber PAHeck DHarvey JChakraborty DBeekman RBCollard KMackenzie LSansing LHBarton KKLegault CSchnieder MEdinger AAPeeling LRedford JThoren MAlemseged FGolsari AChoi MAmiri HLiberato BBarrett SHull GYassi NChmayssani MCagi LJabs JWeisman DCZuniga DMeister SWalker GBarow EVeltkamp RChung JWBellon RJHaussen DNeitz GAlvi TCooray CJovin TMarotta TRWhelan RWortmann GMonteith SJGross BDePalmo ALYang VXDMassengale TNFearon PMaley SSmith WJDay JSYan BKhoury JSKiwan RGoodman DOtto DDeshmukh ASGrunberg IDWright MWilliams JCharlton JRempel JMackey ANaval NSEmery DJMcCabe JJDelucia MWilliams CMoynihan BJLockey APatel PMitha AHargis MSchindler KDeVole NPatel SWu TYVenkatesan PKulandaivel KDukSoo Han EPikula APatel KLynch JJeon PJeon SIancu DNomani AHalpin JSTalley MECutting SMBoutwell CMKiszczak SSposato LABaumle BLiman JFlexman AMTampieri DSettecase FWiggam IWilliams LAJadil NGibson LDeneault NSaposnik GMacMillan SVLaffan ANewcommon NStarr MCamden MCCope KAKouhn LRMisquitta KRoy DHollstein NChow MAshforth RLoochtan AIPaolucci GANakamura CMStotts GKelly MEPiquette LKelly PKotylak TBZhao HGupta ROwer RJYip SDonegan BGuzy JStauder MAghaebrahim Ada Costa LAtchaneeyasakul KCCraft LPJasne ASOvando RMLambourn LButcher KSHeran MKSAbdon WYip JFiehler JCampo MDMann SKShuaib AHannouche MParra-Farinas CKim CHAnne Y Chua JYu AYCalderon MCoveney SAVolny OLopez GASelchen DHGroezinger KMPeters SPereira VSpokoyny IDowling RJSutherly LJEnglish JDStracke PHowk MHolmberg AJahraus CDempsey IPGreen ALMcDonald AHoltz BEnglish SMcDonald CManosalva Alzate HAMontanera WJFontaine BDHicks WJMaluste NDLewis LRangaraju SJaramillo KGayton YKhosravani HPeeling LMArch AEKim BKLi YChen BYHou SYKnapman JMAlshanbari AMBlacquiere DChoe HGubitz GJDeMacedo Rodrigues KChoe JBharatha ABuck BHAsunsian RKinnear RGarner AJMazya MShah RAButt ARaymond JJensen MAlqatani SGriffin LRJackson DBadawy MShoamanesh AKhalil SFlynn PTsoleridis JButt RWalsh RSitaram APatel ASBush SJDiestro JDBSobhi GGraham BRBell KRennie IKupniewski SHanel RALownie SCortes MStys PShah QASteinberg AZiayee HMoore AZulfiqar MBerglund APickett GEWeber RWadhwa ATeitelbaum JJankowitz BDarflinger RJKe MBasto FMZimmel LSimpson CAtchie BNGeorge BPJordan JEMohlenbruch MASchemmel DJPatterson COdier CBrown SYPandey SKChapot RBala FAl-Bayati ARMartin EAgid RPearl HWeeks ADoshi DKapoor AYoon CWBoulton MSauer AKerr EYeo TVan Every CQuateen AGossett MBeck PBurgos AMParsons MWPark HKWilliams DJFrei DFBal SMac Mahon PJGilmore EJHa WUmekubo MSWallocha MHorgan GRedekop GJKuhn ALVora NALlamas-Osorio YAmato-Marziali BFuller LRAmin HLoomis CLynch CTBohn SMartin COWaxman LLee DSohn SIVargas ASilver FLNam HSDavis SMGaal SVDolia JUrroz LWaters MJMaloney WJFaggard JLettow IFalcone GJTememe DJambula AHoe Heo JSahlas DJBenavente ORDesloges IKozak OSCheng BFerreira MAdams KCasaubon LJadhav AArias EJKim SMayich MPrakapenia AKim WJaigobin CKaddouh FTeal PAKhaw AVLimaye KBrown AEby BWang DPetrucci DMBedenk ADurcan LBhatt NNagel SLetourneau JLarrazabal RAJaroenngarmsamer TPatterson JLWira CRPhillips SJAkhtar NSubramanian SLiff JPark HOlds KEToseki Haibach KTennyson-Yemm CRGraham BSa Boasquevisque DRahman HNeuschatz KBBang OYWade KSauvageau EFladt JOjha PHaase KMarnane MJoset DHolst BVieira LKodis LMBarazangi NKalman LPesavento LNarula RDowlatshahi DFernandess JPower SFrontera JDaham ZKing ZPsychogios MNHawkes CBeyrle EWeill AKalashyan HReinke ADrake BAudet MECzerniak JHSchultz MSalvaris PDellorso SMSchindler JLKatz BSScroop RO Kelly CLavoie PKrings TGray KDChoi JKVerreault SKim YDGrossber JShankar JJSMarko MRyckborst KJBrown MJarrett JMassari FMaus VFoley SMNien YLField TSKamra MfalseMediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke.<h4>Importance</h4>Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age is associated with preexisting burdens of brain changes, visible on neuroimaging but rarely considered in acute decision-making or trials, is unknown.<h4>Objectives</h4>To explore the mediation of age on functional outcome by neuroimaging markers of frailty (hereinafter neuroimaging frailty) in patients with acute ischemic stroke receiving endovascular thrombectomy (EVT).<h4>Design, setting, and participants</h4>This cohort study was a post hoc analysis of the Safety and Efficacy of Nerinetide (NA-1) in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1) randomized clinical trial, which investigated intravenous (IV) nerinetide in patients who underwent 2024-01-01T00:00:00Z2024 Jan2025-04-20T02:32:13.745Z2025-04-20T02:32:13.745ZS-EPMC107625753816567610.1001/jamanetworkopen.2023.49628