biostudies-literatureUnknown111(1)Baumgartner R<h4>Background</h4>Arterial lactate measurements were recently suggested as an early predictor of clinically relevant post-hepatectomy liver failure (PHLF). This needed to be evaluated in the subgroup of major hepatectomies only.<h4>Method</h4>This observational cohort study included consecutive elective major hepatectomies at Karolinska University Hospital from 2010 to 2018. Clinical risk factors for PHLF, perioperative arterial lactate measurements and routine lab values were included in uni- and multivariable regression analysis. Receiver operating characteristics and risk cut-offs were calculated.<h4>Results</h4>In total, 649 patients constituted the study cohort, of which 92 developed PHLF grade B/C according to the International Study Group of Liver Surgery (ISGLS). Lactate reached sThe British journal of surgeryznad433https://www.ebi.ac.uk/biostudies/studies/S-EPMC10763542biostudies-literatureComparing the accuracy of prediction models to detect clinically relevant post-hepatectomy liver failure early after major hepatectomy.PMC10763542Gilg SGrip JSparrelid EEngstrand JGhorbani PBaumgartner RRajala PfalseComparing the accuracy of prediction models to detect clinically relevant post-hepatectomy liver failure early after major hepatectomy.<h4>Background</h4>Arterial lactate measurements were recently suggested as an early predictor of clinically relevant post-hepatectomy liver failure (PHLF). This needed to be evaluated in the subgroup of major hepatectomies only.<h4>Method</h4>This observational cohort study included consecutive elective major hepatectomies at Karolinska University Hospital from 2010 to 2018. Clinical risk factors for PHLF, perioperative arterial lactate measurements and routine lab values were included in uni- and multivariable regression analysis. Receiver operating characteristics and risk cut-offs were calculated.<h4>Results</h4>In total, 649 patients constituted the study cohort, of which 92 developed PHLF grade B/C according to the International Study Group of Liver Surgery (ISGLS). Lactate reached s2024-01-01T00:00:00Z2024 Jan2025-04-20T02:32:00.969Z2025-02-19T01:21:12.085ZS-EPMC107635423815018510.1093/bjs/znad433