biostudies-literatureGarland NTDefense Advanced Research Projects AgencyNational Institute of Diabetes and Digestive and Kidney DiseasesNIDDK NIH HHSNorthwestern UniversityNCI NIH HHSMaterials Research Science and Engineering Center, Harvard UniversityNational Science Foundatione2301280https://www.ebi.ac.uk/biostudies/studies/S-EPMC10766868biostudies-literatureUnknown12(28)Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation and mortality, highlighting the critical need for their early detection. Recent demonstrations of wearable sensors enable real-time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery-free wound monitor that measures lactate in real-time and seamlessly integrates with bandages for conformal attachment to the wound bed is introduced. Lactate is selected due to its multifaceted role in initiating healing. Studies in healthy and diabetic mice reveal distinct lactate profiles for normal and impaired healing wounds. A mathematical model based on the sensor data predicts wound closure rate within the first 3 dAdvanced healthcare materialsA Miniaturized, Battery-Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early.PMC10766868R01 DK131302NSF DMR‐1720139R01DK131302P30 CA060553D20AC00004EEC‐1160483Sharma NVazquez-Guardado AHashkavayi ABAmeer GABandodkar AJGaneshan SKVeves ARyu HForsberg VMa TJakus MASong JWGarland NTKim YJKaveti RSumpio BSia SKLee MKRogers JAfalseA Miniaturized, Battery-Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early.Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation and mortality, highlighting the critical need for their early detection. Recent demonstrations of wearable sensors enable real-time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery-free wound monitor that measures lactate in real-time and seamlessly integrates with bandages for conformal attachment to the wound bed is introduced. Lactate is selected due to its multifaceted role in initiating healing. Studies in healthy and diabetic mice reveal distinct lactate profiles for normal and impaired healing wounds. A mathematical model based on the sensor data predicts wound closure rate within the first 3 d2023-01-01T00:00:00Z2023 Nov2025-04-04T03:01:01.169Z2025-04-04T03:01:01.169ZS-EPMC107668683740703010.1002/adhm.202301280