{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Islam MA"],"funding":["Jayne Koskinas Ted Giovanis Foundation for Health and Policy","University at Buffalo","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e1011741"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10769079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(12)"],"pubmed_abstract":["The severity of the COVID-19 pandemic has created an emerging need to investigate the long-term effects of infection on patients. Many individuals are at risk of suffering pulmonary fibrosis due to the pathogenesis of lung injury and impairment in the healing mechanism. Fibroblasts are the central mediators of extracellular matrix (ECM) deposition during tissue regeneration, regulated by anti-inflammatory cytokines including transforming growth factor beta (TGF-β). The TGF-β-dependent accumulation of fibroblasts at the damaged site and excess fibrillar collagen deposition lead to fibrosis. We developed an open-source, multiscale tissue simulator to investigate the role of TGF-β sources in the progression of lung fibrosis after SARS-CoV-2 exposure, intracellular viral replication, infection"],"journal":["PLoS computational biology"],"pubmed_title":["An agent-based modeling approach for lung fibrosis in response to COVID-19."],"pmcid":["PMC10769079"],"funding_grant_id":["startup funds","R35 GM133763","R35GM133763"],"pubmed_authors":["Islam MA","Ford Versypt AN","Getz M","Macklin P"],"additional_accession":[]},"is_claimable":false,"name":"An agent-based modeling approach for lung fibrosis in response to COVID-19.","description":"The severity of the COVID-19 pandemic has created an emerging need to investigate the long-term effects of infection on patients. Many individuals are at risk of suffering pulmonary fibrosis due to the pathogenesis of lung injury and impairment in the healing mechanism. Fibroblasts are the central mediators of extracellular matrix (ECM) deposition during tissue regeneration, regulated by anti-inflammatory cytokines including transforming growth factor beta (TGF-β). The TGF-β-dependent accumulation of fibroblasts at the damaged site and excess fibrillar collagen deposition lead to fibrosis. We developed an open-source, multiscale tissue simulator to investigate the role of TGF-β sources in the progression of lung fibrosis after SARS-CoV-2 exposure, intracellular viral replication, infection","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-04T21:28:24.967Z","creation":"2025-02-19T03:18:04.303Z"},"accession":"S-EPMC10769079","cross_references":{"pubmed":["38127835"],"doi":["10.1371/journal.pcbi.1011741"]}}