{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang JH"],"funding":["National Institute of Neurological Disorders and Stroke","NCI NIH HHS","NINDS NIH HHS"],"pagination":["10045-10050"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10769484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(18)"],"pubmed_abstract":["Real-time detection of bio-event in whole animals provides essential information for understanding biological and therapeutic processes. Magnetic resonance (MR) imaging represents a non-invasive approach to generating three-dimensional anatomic images with high spatial-temporal resolution and unlimited depth penetration. We have developed several self-immolative enzyme-activatable agents that provide excellent in vivo contrast and function as gene expression reporters. Here, we describe a vast improvement in image contrast over our previous generations of these bioresponsive agents based on a new pyridyl-carbamate Gd(III) complex. The pyridyl-carbamate-based agent has a very low MR relaxivity in the \"off-state\" (<i>r</i><sub>1</sub> = 1.8 mM<sup>-1</sup> s<sup>-1</sup> at 1.41 T). However,"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Molecular Engineering of Self-Immolative Bioresponsive MR Probes."],"pmcid":["PMC10769484"],"funding_grant_id":["R01 NS115571","P30 CA060553","5R01NS115571"],"pubmed_authors":["Luchinat C","Li H","Yuan C","Tang JH","Meade TJ","Parigi G"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Engineering of Self-Immolative Bioresponsive MR Probes.","description":"Real-time detection of bio-event in whole animals provides essential information for understanding biological and therapeutic processes. Magnetic resonance (MR) imaging represents a non-invasive approach to generating three-dimensional anatomic images with high spatial-temporal resolution and unlimited depth penetration. We have developed several self-immolative enzyme-activatable agents that provide excellent in vivo contrast and function as gene expression reporters. Here, we describe a vast improvement in image contrast over our previous generations of these bioresponsive agents based on a new pyridyl-carbamate Gd(III) complex. The pyridyl-carbamate-based agent has a very low MR relaxivity in the \"off-state\" (<i>r</i><sub>1</sub> = 1.8 mM<sup>-1</sup> s<sup>-1</sup> at 1.41 T). However,","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-06-02T01:39:03.648Z","creation":"2025-02-19T03:18:02.375Z"},"accession":"S-EPMC10769484","cross_references":{"pubmed":["37116079"],"doi":["10.1021/jacs.2c13672"]}}