{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45(1)"],"submitter":["Yang ZX"],"pubmed_abstract":["The gut-brain axis plays a vital role in Parkinson's disease (PD). The mechanisms of gut-brain transmission mainly focus on α-synuclein deposition, intestinal inflammation and microbiota function. A few studies have shown the trigger of PD pathology in the gut. α-Synuclein is highly conserved in food products, which was able to form β-folded aggregates and to infect the intestinal mucosa. In this study we investigated whether α-synuclein-preformed fibril (PFF) exposure could modulate the intestinal environment and induce rodent models replicating PD pathology. We first showed that PFF could be internalized into co-cultured Caco-2/HT29/Raji b cells in vitro. Furthermore, we demonstrated that PFF perfusion caused the intestinal inflammation and activation of enteric glial cells in an ex vivo"],"journal":["Acta pharmacologica Sinica"],"pagination":["36-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10770087"],"repository":["biostudies-literature"],"pubmed_title":["Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems."],"pmcid":["PMC10770087"],"pubmed_authors":["Yang ZX","Wang Q","Zhang Y","Zhou C","Ren Y","Liu YF","Zhang L","Gao HW","Zhang NX","Feng LY"],"additional_accession":[]},"is_claimable":false,"name":"Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems.","description":"The gut-brain axis plays a vital role in Parkinson's disease (PD). The mechanisms of gut-brain transmission mainly focus on α-synuclein deposition, intestinal inflammation and microbiota function. A few studies have shown the trigger of PD pathology in the gut. α-Synuclein is highly conserved in food products, which was able to form β-folded aggregates and to infect the intestinal mucosa. In this study we investigated whether α-synuclein-preformed fibril (PFF) exposure could modulate the intestinal environment and induce rodent models replicating PD pathology. We first showed that PFF could be internalized into co-cultured Caco-2/HT29/Raji b cells in vitro. Furthermore, we demonstrated that PFF perfusion caused the intestinal inflammation and activation of enteric glial cells in an ex vivo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-04T21:49:09.392Z","creation":"2025-04-04T21:49:09.392Z"},"accession":"S-EPMC10770087","cross_references":{"pubmed":["37684382"],"doi":["10.1038/s41401-023-01150-2"]}}