biostudies-literatureYang Zkey research and development project of Jilin Provincial Science and Technology DepartmentInterdisciplinary innovation project of the first hospital of Jilin Universitythe scientific research foundation of the first hospital of Jilin Universitythe WU JIEPING MEDICAL FOUNDATIONNatural Science Foundation of Jilin Provincethe Science and Technology Research Project of Jilin Provincial Department of Education22https://www.ebi.ac.uk/biostudies/studies/S-EPMC10770976biostudies-literatureUnknown22(1)The accurate preoperative diagnosis and tracking of lung adenocarcinoma is hindered by non-targeting and diffusion of dyes used for marking tumors. Hence, there is an urgent need to develop a practical nanoprobe for tracing lung adenocarcinoma precisely even treating them noninvasively. Herein, Gold nanoclusters (AuNCs) conjugate with thyroid transcription factor-1 (TTF-1) antibody, then multifunctional nanoprobe Au-TTF-1 is designed and synthesized, which underscores the paramount importance of advancing the machine learning diagnosis and bioimaging-guided treatment of lung adenocarcinoma. Bright fluorescence (FL) and strong CT signal of Au-TTF-1 set the stage for tracking. Furthermore, the high specificity of TTF-1 antibody facilitates selective targeting of lung adenocarcinoma cells as Journal of nanobiotechnology"All in one" nanoprobe Au-TTF-1 for target FL/CT bioimaging, machine learning technology and imaging-guided photothermal therapy against lung adenocarcinoma.PMC10770976***202302002JJKH20211203KJ320.6750.19089.8020210204142YYJDYYJCHX2020005JDYY11202015Yang XSong LYang ZLi YLin QTang LZhang YZvyagin AVShen CYang Bfalse"All in one" nanoprobe Au-TTF-1 for target FL/CT bioimaging, machine learning technology and imaging-guided photothermal therapy against lung adenocarcinoma.The accurate preoperative diagnosis and tracking of lung adenocarcinoma is hindered by non-targeting and diffusion of dyes used for marking tumors. Hence, there is an urgent need to develop a practical nanoprobe for tracing lung adenocarcinoma precisely even treating them noninvasively. Herein, Gold nanoclusters (AuNCs) conjugate with thyroid transcription factor-1 (TTF-1) antibody, then multifunctional nanoprobe Au-TTF-1 is designed and synthesized, which underscores the paramount importance of advancing the machine learning diagnosis and bioimaging-guided treatment of lung adenocarcinoma. Bright fluorescence (FL) and strong CT signal of Au-TTF-1 set the stage for tracking. Furthermore, the high specificity of TTF-1 antibody facilitates selective targeting of lung adenocarcinoma cells as 2024-01-01T00:00:00Z2024 Jan2025-04-04T21:28:40.314Z2024-12-04T10:29:45.275ZS-EPMC107709763818462010.1186/s12951-023-02280-9