{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gay BL"],"funding":["Division of Chemistry","Amgen","University of Texas at Austin","Stephen F. Austin State University","Welch Foundation","National Institute of General Medical Sciences","NIGMS NIH HHS","Eli Lilly and Company","Novartis"],"pagination":["18939-18947"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10772865"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(34)"],"pubmed_abstract":["Aminoboration of simple alkenes with nitrogen nucleophiles remains an unsolved problem in synthetic chemistry; this transformation can be catalyzed by palladium <i>via</i> aminopalladation followed by transmetalation with a diboron reagent. However, this catalytic process faces inherent challenges with instability of the alkylpalladium(II) intermediate toward β-hydride elimination. Herein, we report a palladium/iron cocatalyzed aminoboration, which enables this transformation. We demonstrate these conditions on a variety of alkenes and norbornenes with an array of common nitrogen nucleophiles. In the developed strategy, the iron cocatalyst is crucial to achieving the desired reactivity by serving as a halophilic Lewis acid to release the transmetalation-active cationic alkylpalladium inter"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration."],"pmcid":["PMC10772865"],"funding_grant_id":["R01 GM111480","FG-2016-6568","R35 GM125029","2155133"],"pubmed_authors":["Tarasewicz A","Wang YN","Neidig ML","Cooke DJ","Gary JB","Gay BL","Zhang B","Bhatt S","Milem EG","Hull KL"],"additional_accession":[]},"is_claimable":false,"name":"Palladium and Iron Cocatalyzed Aerobic Alkene Aminoboration.","description":"Aminoboration of simple alkenes with nitrogen nucleophiles remains an unsolved problem in synthetic chemistry; this transformation can be catalyzed by palladium <i>via</i> aminopalladation followed by transmetalation with a diboron reagent. However, this catalytic process faces inherent challenges with instability of the alkylpalladium(II) intermediate toward β-hydride elimination. Herein, we report a palladium/iron cocatalyzed aminoboration, which enables this transformation. We demonstrate these conditions on a variety of alkenes and norbornenes with an array of common nitrogen nucleophiles. In the developed strategy, the iron cocatalyst is crucial to achieving the desired reactivity by serving as a halophilic Lewis acid to release the transmetalation-active cationic alkylpalladium inter","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-05-18T12:53:32.54Z","creation":"2025-05-18T12:53:32.54Z"},"accession":"S-EPMC10772865","cross_references":{"pubmed":["37584107"],"doi":["10.1021/jacs.3c05790"]}}