{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee JS"],"funding":["National Research Foundation of Korea"],"pagination":["34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10773012"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Objectives</h4>Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date.<h4>Methods</h4>Based on clinical clues, we hypothesized that 5-hydroxytryptamine (5-HT) hyperactivation is implicated in the pathogenic causes of ME/CFS and the associated symptoms. We experimentally evaluated this hypothesis in a series of mouse models.<h4>Results</h4>High-dose selective serotonin reuptake inhibitor (SSRI) treatment induced intra- and extracellular serotonin spillover in the dorsal raphe nuclei of mice. This condition resulted in severe fatigue (rota-rod, fatigue rotating wheel and home-cage activity tests) and ME/CFS-associated symptoms (nest building, plantar and open field test), along w"],"journal":["Journal of translational medicine"],"pubmed_title":["Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology."],"pmcid":["PMC10773012"],"funding_grant_id":["NRF-2018R1A6A1A03025221"],"pubmed_authors":["Lee JS","Hwang SJ","Son CG","Bae SJ","Kang JY","Park SY"],"additional_accession":[]},"is_claimable":false,"name":"Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology.","description":"<h4>Objectives</h4>Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date.<h4>Methods</h4>Based on clinical clues, we hypothesized that 5-hydroxytryptamine (5-HT) hyperactivation is implicated in the pathogenic causes of ME/CFS and the associated symptoms. We experimentally evaluated this hypothesis in a series of mouse models.<h4>Results</h4>High-dose selective serotonin reuptake inhibitor (SSRI) treatment induced intra- and extracellular serotonin spillover in the dorsal raphe nuclei of mice. This condition resulted in severe fatigue (rota-rod, fatigue rotating wheel and home-cage activity tests) and ME/CFS-associated symptoms (nest building, plantar and open field test), along w","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-03-31T10:55:52.536Z","creation":"2025-04-06T09:22:45.201Z"},"accession":"S-EPMC10773012","cross_references":{"pubmed":["38191373"],"doi":["10.1186/s12967-023-04808-x"]}}