biostudies-literatureUnknown14(1)Deja E<h4>Objectives</h4>The Bronchiolitis Endotracheal Surfactant Study (BESS) is a randomised controlled trial to determine the efficacy of endo-tracheal surfactant therapy for critically ill infants with bronchiolitis. To explore acceptability of BESS, including approach to consent within a limited time frame, we explored parent and staff experiences of trial involvement in the first two bronchiolitis seasons to inform subsequent trial conduct.<h4>Design</h4>A mixed-method embedded study involving a site staff survey, questionnaires and interviews with parents approached about BESS.<h4>Setting</h4>Fourteen UK paediatric intensive care units.<h4>Participants</h4>Of the 179 parents of children approached to take part in BESS, 75 parents (of 69 children) took part in the embedded study. Of theseBMJ opene077023https://www.ebi.ac.uk/biostudies/studies/S-EPMC10773389biostudies-literatureStakeholders' perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study.PMC10773389Osman AAli AMWoolfall KMogan SSundararajan SPlayfor SDMcNamara PSArmstrong DPlaatjies NColes SBeadon KThorn NPatel RJennings CFScriven EDavies PECunningham SPaulson SMinchin HRiley EKPostle ARonan CMcCormick JRichardson JParslow RPeak MFox SMackerness CPond JCook AStiven JOwen SParkin HLyons JPostlethwaite CBrowne WMellish CPreston JBest ASummers CPanchal MLo TYGriksaitis MMorgan DJMadsen JReed SJones AJones DRad LTerris MClark HWTurner MMander MCrate LRitson PCDawson AReeves KSemple MGPrice LSiddiqi SBESS InvestigatorsMilner PMarley HLinton VWood AAllen EMcCorkell JTooke CClarke HMiert CVSarfatti ALinton CCurtis TDeja ERoberts NWeitz JPappachan JKanaris CClaydon RThompson CThorburn KBaptiste KMurray TWinmill HClarke SBarker CKumar RJirasek PKnott CFowler CChild HKirupananthan RMorris KPMilburn NNugent OSinfield FMcMinnis RNelson CBrincat EBunni LTParker HCallaghan HLampariello SRamaiah RNCaruana LCompton VDavis PJSchadenberg AO'Malley LLamb CMarscheider RMcClelland NMoitt TCipriano BEames SJStancombe AEtherington NAlexander JTomlinson JRamesh PWilliamson GAlexander CAgbeko RWilliamson PKhalid NMarshall RTeeley KGavin BCOsaghae BOliver ZGates SRimmer LPayne HLevin RDonohue CSimons CfalseStakeholders' perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study.<h4>Objectives</h4>The Bronchiolitis Endotracheal Surfactant Study (BESS) is a randomised controlled trial to determine the efficacy of endo-tracheal surfactant therapy for critically ill infants with bronchiolitis. To explore acceptability of BESS, including approach to consent within a limited time frame, we explored parent and staff experiences of trial involvement in the first two bronchiolitis seasons to inform subsequent trial conduct.<h4>Design</h4>A mixed-method embedded study involving a site staff survey, questionnaires and interviews with parents approached about BESS.<h4>Setting</h4>Fourteen UK paediatric intensive care units.<h4>Participants</h4>Of the 179 parents of children approached to take part in BESS, 75 parents (of 69 children) took part in the embedded study. Of these2024-01-01T00:00:00Z2024 Jan2025-04-03T21:31:07.55Z2025-04-03T21:31:07.55ZS-EPMC107733893816728010.1136/bmjopen-2023-077023