{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alexander EC"],"funding":["UK Department of Health and Social Care","Barts Charity","NHS","NIHR Academic Clinical Fellowship","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["S1-S11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10773669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["190(1)"],"pubmed_abstract":["<h4>Objective</h4>Hypogonadotropic hypogonadism is characterized by inadequate secretion of pituitary gonadotropins, leading to absent, partial, or arrested puberty. In males, classical treatment with testosterone promotes virilization but not testicular growth or spermatogenesis. To quantify treatment practices and efficacy, we systematically reviewed all studies investigating gonadotropins for the achievement of pubertal outcomes in males with hypogonadotropic hypogonadism.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>A systematic review of Medline, Embase, Global Health, and PsycINFO databases in December 2022. Risk of Bias 2.0/Risk Of Bias In Non-randomized Studies of Interventions/National Heart, Lung, and Blood Institute tools for quality appraisal. Protocol regi"],"journal":["European journal of endocrinology"],"pubmed_title":["Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis."],"pmcid":["PMC10773669"],"funding_grant_id":["222049/Z/20/Z","ACF-2021-19-002","MGU0552"],"pubmed_authors":["Hoskyns R","Ng Yin K","Alexander EC","Varughese R","Faruqi D","Farquhar R","Howard SR","Unadkat A"],"additional_accession":[]},"is_claimable":false,"name":"Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.","description":"<h4>Objective</h4>Hypogonadotropic hypogonadism is characterized by inadequate secretion of pituitary gonadotropins, leading to absent, partial, or arrested puberty. In males, classical treatment with testosterone promotes virilization but not testicular growth or spermatogenesis. To quantify treatment practices and efficacy, we systematically reviewed all studies investigating gonadotropins for the achievement of pubertal outcomes in males with hypogonadotropic hypogonadism.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>A systematic review of Medline, Embase, Global Health, and PsycINFO databases in December 2022. Risk of Bias 2.0/Risk Of Bias In Non-randomized Studies of Interventions/National Heart, Lung, and Blood Institute tools for quality appraisal. Protocol regi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-12T05:51:44.778Z","creation":"2025-04-04T21:29:05.284Z"},"accession":"S-EPMC10773669","cross_references":{"pubmed":["38128110"],"doi":["10.1093/ejendo/lvad166"]}}