biostudies-literatureUnknown106(1)Kong Q<h4>Purpose</h4>Whether patients suffering liver oligometastases from pancreatic ductal adenocarcinoma (LOPDA) should undergo surgical treatment remains controversial.<h4>Methods</h4>PubMed and Embase databases were systematically reviewed until 2023 June. Survival data were collected from the Kaplan-Meier curves. Safety and survival were evaluated using primary outcomes such as 1-year, 3-year, and 5-year survival rates, and 30-day mortality and morbidity. A subgroup meta-analysis was conducted to compare survival rates post-synchronous resection and resection post-neoadjuvant chemotherapy in LOPDA.<h4>Results</h4>Our analysis of 15 studies involving 1,818 patients (surgical group, 648 and nonsurgical group, 1,170) indicates that radical hepatectomy for LOPDA notably improved 1-year (odds Annals of surgical treatment and research51-60https://www.ebi.ac.uk/biostudies/studies/S-EPMC10774701biostudies-literatureRadical resection benefits patients suffering pancreatic ductal adenocarcinoma with liver oligometastases.PMC10774701Li HKong QChen ZTeng FfalseRadical resection benefits patients suffering pancreatic ductal adenocarcinoma with liver oligometastases.<h4>Purpose</h4>Whether patients suffering liver oligometastases from pancreatic ductal adenocarcinoma (LOPDA) should undergo surgical treatment remains controversial.<h4>Methods</h4>PubMed and Embase databases were systematically reviewed until 2023 June. Survival data were collected from the Kaplan-Meier curves. Safety and survival were evaluated using primary outcomes such as 1-year, 3-year, and 5-year survival rates, and 30-day mortality and morbidity. A subgroup meta-analysis was conducted to compare survival rates post-synchronous resection and resection post-neoadjuvant chemotherapy in LOPDA.<h4>Results</h4>Our analysis of 15 studies involving 1,818 patients (surgical group, 648 and nonsurgical group, 1,170) indicates that radical hepatectomy for LOPDA notably improved 1-year (odds 2024-01-01T00:00:00Z2024 Jan2025-04-04T13:58:48.313Z2025-04-04T13:58:48.313ZS-EPMC107747013820509410.4174/astr.2024.106.1.51