{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ozga M"],"funding":["NCI NIH HHS"],"pagination":["45-57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10776397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(1)"],"pubmed_abstract":["Clinical outcome of patients with acute myeloid leukemia (AML) is associated with demographic and genetic features. Although the associations of acquired genetic alterations with patients' sex have been recently analyzed, their impact on outcome of female and male patients has not yet been comprehensively assessed. We performed mutational profiling, cytogenetic and outcome analyses in 1726 adults with AML (749 female and 977 male) treated on frontline Alliance for Clinical Trials in Oncology protocols. A validation cohort comprised 465 women and 489 men treated on frontline protocols of the German AML Cooperative Group. Compared with men, women more often had normal karyotype, FLT3-ITD, DNMT3A, NPM1 and WT1 mutations and less often complex karyotype, ASXL1, SRSF2, U2AF1, RUNX1, or KIT muta"],"journal":["Leukemia"],"pubmed_title":["Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG)."],"pmcid":["PMC10776397"],"funding_grant_id":["UG1 CA233247","UG1 CA233339","R35 CA197734","R01 CA262496","UG1 CA233327","UG1 CA233338","U10 CA023318","UG1 CA189824","P30 CA016058","U10 CA180882","UG1 CA233180","UG1 CA189850","R01 CA283574","U10 CA180867","U24 CA196171","U10 CA180821","R01 CA226802","UG1 CA233331","P50 CA140158","UG1 CA233253"],"pubmed_authors":["Braess J","Herold T","Jurinovic V","Larkin KT","Sauerland MC","Larson RA","Stock W","Mrozek K","Nicolet D","Mims AS","Dufour A","Mayer RJ","Metzeler KH","Grimes HL","Gorlich D","Berdel WE","Powell BL","Byrd JC","Eisfeld AK","Spiekermann K","Kolitz JE","Ozga M","Schneider S","Uy GL","Blum WG","Subklewe M","Moore JO","Blachly JS","Oakes CC","Woermann BJ","Hiddemann W","Krug U","Carroll AJ","Salomonis N","Kohlschmidt J","Orwick S","Buss J","Rothenberg-Thurley M","Yilmaz AS","Walker CJ"],"additional_accession":[]},"is_claimable":false,"name":"Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG).","description":"Clinical outcome of patients with acute myeloid leukemia (AML) is associated with demographic and genetic features. Although the associations of acquired genetic alterations with patients' sex have been recently analyzed, their impact on outcome of female and male patients has not yet been comprehensively assessed. We performed mutational profiling, cytogenetic and outcome analyses in 1726 adults with AML (749 female and 977 male) treated on frontline Alliance for Clinical Trials in Oncology protocols. A validation cohort comprised 465 women and 489 men treated on frontline protocols of the German AML Cooperative Group. Compared with men, women more often had normal karyotype, FLT3-ITD, DNMT3A, NPM1 and WT1 mutations and less often complex karyotype, ASXL1, SRSF2, U2AF1, RUNX1, or KIT muta","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-02T11:22:43.394Z","creation":"2024-11-09T13:39:43.682Z"},"accession":"S-EPMC10776397","cross_references":{"pubmed":["38017103"],"doi":["10.1038/s41375-023-02068-8"]}}