biostudies-literatureYang CRMinistry of Science and Technology, TaiwanChina Medical University, TaiwanAsia University HospitalNational Health Research InstitutesNational Science and Technology CouncilChina Medical University Hospital6https://www.ebi.ac.uk/biostudies/studies/S-EPMC10777576biostudies-literatureUnknown12(1)<h4>Background</h4>Metabolic associated steatohepatitis (MASH) is metabolic disease that may progress to cirrhosis and hepatocellular carcinoma. Mouse models of diet-induced MASH, which is characterized by the high levels of fats, sugars, and cholesterol in diets, are commonly used in research. However, mouse models accurately reflecting the progression of MASH in humans remain to be established. Studies have explored the potential use of serological metabolites as biomarkers of MASH severity in relation to human MASH.<h4>Methods</h4>We performed a comparative analysis of three mouse models of diet-induced MASH in terms of phenotypic and metabolomic characteristics; MASH was induced using different diets: a high-fat diet; a Western diet; and a high-fat, high-cholesterol diet. Liver cirrhosBiomarker researchPhenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis.PMC10777576NSTC 112-2320-B-039-005MOST 110-2314-B-039-046AUH-11151021CMU111-MF-41NHRI-EX112-11110BICMU109-MF-26DMR-110-025NSTC 111-2622-B-039-004MOST 111-2314-B-039-062-MY3MOST 111-2320-B-039-011Yang CRLai HCHung YCLin WJMa WLShen PCLiao PYDai YCMehmood SCheng WCfalsePhenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis.<h4>Background</h4>Metabolic associated steatohepatitis (MASH) is metabolic disease that may progress to cirrhosis and hepatocellular carcinoma. Mouse models of diet-induced MASH, which is characterized by the high levels of fats, sugars, and cholesterol in diets, are commonly used in research. However, mouse models accurately reflecting the progression of MASH in humans remain to be established. Studies have explored the potential use of serological metabolites as biomarkers of MASH severity in relation to human MASH.<h4>Methods</h4>We performed a comparative analysis of three mouse models of diet-induced MASH in terms of phenotypic and metabolomic characteristics; MASH was induced using different diets: a high-fat diet; a Western diet; and a high-fat, high-cholesterol diet. Liver cirrhos2024-01-01T00:00:00Z2024 Jan2026-06-03T14:56:40.137Z2024-12-04T08:30:53.976ZS-EPMC107775763819558710.1186/s40364-023-00555-9