biostudies-literatureUnknown24(1)Chen Z<h4>Background</h4>This study investigates the variations in microbiome abundance and diversity on the ocular surfaces of diabetic patients suffering from dry eye within a community setting. The goal is to offer theoretical insights for the community-level prevention and treatment of dry eye in diabetic cohorts.<h4>Methods</h4>Dry eye screening was performed in the Shanghai Cohort Study of Diabetic Eye Disease (SCODE) from July 15, 2021, to August 15, 2021, in the Xingjing community; this study included both a population with diabetes and a normal population. The population with diabetes included a dry eye group (DM-DE, n = 40) and a non-dry eye group (DM-NoDE, n = 39). The normal population included a dry eye group (NoDM-DE, n = 40) and a control group (control, n = 39). High-throughput sBMC microbiology19https://www.ebi.ac.uk/biostudies/studies/S-EPMC10777597biostudies-literatureUnique composition of ocular surface microbiome in the old patients with dry eye and diabetes mellitus in a community from Shanghai, China.PMC10777597Zou HLu LLin SChen ZXu YfalseUnique composition of ocular surface microbiome in the old patients with dry eye and diabetes mellitus in a community from Shanghai, China.<h4>Background</h4>This study investigates the variations in microbiome abundance and diversity on the ocular surfaces of diabetic patients suffering from dry eye within a community setting. The goal is to offer theoretical insights for the community-level prevention and treatment of dry eye in diabetic cohorts.<h4>Methods</h4>Dry eye screening was performed in the Shanghai Cohort Study of Diabetic Eye Disease (SCODE) from July 15, 2021, to August 15, 2021, in the Xingjing community; this study included both a population with diabetes and a normal population. The population with diabetes included a dry eye group (DM-DE, n = 40) and a non-dry eye group (DM-NoDE, n = 39). The normal population included a dry eye group (NoDM-DE, n = 40) and a control group (control, n = 39). High-throughput s2024-01-01T00:00:00Z2024 Jan2025-08-27T03:07:30.255Z2025-08-27T03:07:30.255ZS-EPMC107775973820041810.1186/s12866-023-03176-2