{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Forbord KM"],"funding":["Norwegian Pharmaceutical Society","Garvan Institute of Medical Research and St. Vincent’s Clinical School, Sydney, Australia","Olav Thon Foundation and the University of Oslo, Norway","University of Copenhagen, Odense University Hospital, and University of Southern Denmark, Denmark","Gerda og Aage Haenschs Fond, Direktør Michael Hermann Nielsens mindelegat, Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis’ Legat","Olav Thon (Norway)"],"pagination":["36"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10778535"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Legumain is a lysosomal cysteine protease that has been implicated in an increasing amount of physiological and pathophysiological processes. However, the upstream mechanisms regulating the expression and function of legumain are not well understood. Here, we provide in vitro and in vivo data showing that vitamin D<sub>3</sub> (VD<sub>3</sub>) enhances legumain expression and function. In turn, legumain alters VD<sub>3</sub> bioavailability, possibly through proteolytic cleavage of vitamin D binding protein (VDBP). Active VD<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>) increased legumain expression, activity, and secretion in osteogenic cultures of human bone marrow stromal cells. Upregulation of legumain was also observed in vivo, evidenced by increased legumain mRNA in the liver and s"],"journal":["Cells"],"pubmed_title":["The Cysteine Protease Legumain Is Upregulated by Vitamin D and Is a Regulator of Vitamin D Metabolism in Mice."],"pmcid":["PMC10778535"],"funding_grant_id":["No grant number"],"pubmed_authors":["Forbord KM","Jafari A","Hesselson D","Solberg R","Tang JCY","Okla M","Arnekleiv G","Lunde NN","Kassem M","Bosnjak-Olsen T","Johansen HT"],"additional_accession":[]},"is_claimable":false,"name":"The Cysteine Protease Legumain Is Upregulated by Vitamin D and Is a Regulator of Vitamin D Metabolism in Mice.","description":"Legumain is a lysosomal cysteine protease that has been implicated in an increasing amount of physiological and pathophysiological processes. However, the upstream mechanisms regulating the expression and function of legumain are not well understood. Here, we provide in vitro and in vivo data showing that vitamin D<sub>3</sub> (VD<sub>3</sub>) enhances legumain expression and function. In turn, legumain alters VD<sub>3</sub> bioavailability, possibly through proteolytic cleavage of vitamin D binding protein (VDBP). Active VD<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>) increased legumain expression, activity, and secretion in osteogenic cultures of human bone marrow stromal cells. Upregulation of legumain was also observed in vivo, evidenced by increased legumain mRNA in the liver and s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-04-15T03:20:13.769Z","creation":"2024-10-16T00:16:10.578Z"},"accession":"S-EPMC10778535","cross_references":{"pubmed":["38201240"],"doi":["10.3390/cells13010036"]}}