{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Mourtada J"],"pubmed_abstract":["The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These glycoproteins play crucial roles in various biological processes, and especially modulation of the Wnt signaling pathway. DKK-3 is distinct, with its multifaceted roles in development, stem cell differentiation and tissue homeostasis. Intriguingly, DKK-3 appears to have immunomodulatory functions and a complex role in cancer, acting as either a tumor suppressor or an oncogene, depending on the context. DKK-3 is a promising diagnostic and therapeutic target that can be modulated by epigenetic reactivation, gene therapy and DKK-3-blocking agents. However, further research is needed to optimize DKK-3-based therapies. In this r"],"journal":["Cells"],"pagination":["75"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10778571"],"repository":["biostudies-literature"],"pubmed_title":["The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer."],"pmcid":["PMC10778571"],"pubmed_authors":["Wasylyk B","Mourtada J","Thibaudeau C","Jung AC"],"additional_accession":[]},"is_claimable":false,"name":"The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer.","description":"The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These glycoproteins play crucial roles in various biological processes, and especially modulation of the Wnt signaling pathway. DKK-3 is distinct, with its multifaceted roles in development, stem cell differentiation and tissue homeostasis. Intriguingly, DKK-3 appears to have immunomodulatory functions and a complex role in cancer, acting as either a tumor suppressor or an oncogene, depending on the context. DKK-3 is a promising diagnostic and therapeutic target that can be modulated by epigenetic reactivation, gene therapy and DKK-3-blocking agents. However, further research is needed to optimize DKK-3-based therapies. In this r","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-19T18:59:08.143Z","creation":"2025-04-19T18:59:08.143Z"},"accession":"S-EPMC10778571","cross_references":{"pubmed":["38201279"],"doi":["10.3390/cells13010075"]}}