{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arabkari V"],"funding":["Irish Research Council","University of Galway"],"pagination":["186"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10778669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["X-box binding protein 1 (XBP1) is a transcription factor that plays a crucial role in the unfolded protein response (UPR), a cellular stress response pathway involved in maintaining protein homeostasis in the endoplasmic reticulum (EnR). While the role of XBP1 in UPR is well-characterised, emerging evidence suggests its involvement in endocrine resistance in breast cancer. The transcriptional activity of spliced XBP1 (XBP1s) is a major component of its biological effects, but the targets of XBP1s in estrogen receptor (ER)-positive breast cancer are not well understood. Here, we show that the expression of miR-378 and PPARGC1B (host gene of miR-378) is downregulated during UPR. Using chemical and genetic methods, we show that XBP1s is necessary and sufficient for the downregulation of miR-3"],"journal":["International journal of molecular sciences"],"pubmed_title":["miRNA-378 Is Downregulated by XBP1 and Inhibits Growth and Migration of Luminal Breast Cancer Cells."],"pmcid":["PMC10778669"],"funding_grant_id":["GOIPG/2016/1189"],"pubmed_authors":["Gupta A","Arabkari V","Webber M","Gupta S","Smith T","Hossain MM","Barua D"],"additional_accession":[]},"is_claimable":false,"name":"miRNA-378 Is Downregulated by XBP1 and Inhibits Growth and Migration of Luminal Breast Cancer Cells.","description":"X-box binding protein 1 (XBP1) is a transcription factor that plays a crucial role in the unfolded protein response (UPR), a cellular stress response pathway involved in maintaining protein homeostasis in the endoplasmic reticulum (EnR). While the role of XBP1 in UPR is well-characterised, emerging evidence suggests its involvement in endocrine resistance in breast cancer. The transcriptional activity of spliced XBP1 (XBP1s) is a major component of its biological effects, but the targets of XBP1s in estrogen receptor (ER)-positive breast cancer are not well understood. Here, we show that the expression of miR-378 and PPARGC1B (host gene of miR-378) is downregulated during UPR. Using chemical and genetic methods, we show that XBP1s is necessary and sufficient for the downregulation of miR-3","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-05-18T03:12:07.888Z","creation":"2026-05-18T03:07:29.084Z"},"accession":"S-EPMC10778669","cross_references":{"pubmed":["38203358"],"doi":["10.3390/ijms25010186"]}}