{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Z"],"funding":["Shaanxi Provincial Science and Technology Department","National Natural Science Foundation of China"],"pagination":["729-741"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10787014"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(4)"],"pubmed_abstract":["Spermatogenesis is a continual process that occurs in the testes, in which diploid spermatogonial stem cells (SSCs) differentiate and generate haploid spermatozoa. This highly efficient and intricate process is orchestrated at multiple levels. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), an epigenetic modification prevalent in mRNAs, is implicated in the transcriptional regulation during spermatogenesis. However, the dynamics of m<sup>6</sup>A modification in non-rodent mammalian species remains unclear. Here, we systematically investigated the profile and role of m<sup>6</sup>A during spermatogenesis in pigs. By analyzing the transcriptomic distribution of m<sup>6</sup>A in spermatogonia, spermatocytes, and round spermatids, we identified a globally conserved m<sup>6</sup>A pattern bet"],"journal":["Genomics, proteomics & bioinformatics"],"pubmed_title":["Transcriptome-wide Dynamics of m<sup>6</sup>A mRNA Methylation During Porcine Spermatogenesis."],"pmcid":["PMC10787014"],"funding_grant_id":["81703193","2020NY-003","31572401"],"pubmed_authors":["Zheng Y","Li F","Lv Y","Zhang L","Zeng W","Zhang P","Li X","Liu Z","Huang T","Zhang T","Lu H","Yu T","Chen X"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome-wide Dynamics of m<sup>6</sup>A mRNA Methylation During Porcine Spermatogenesis.","description":"Spermatogenesis is a continual process that occurs in the testes, in which diploid spermatogonial stem cells (SSCs) differentiate and generate haploid spermatozoa. This highly efficient and intricate process is orchestrated at multiple levels. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), an epigenetic modification prevalent in mRNAs, is implicated in the transcriptional regulation during spermatogenesis. However, the dynamics of m<sup>6</sup>A modification in non-rodent mammalian species remains unclear. Here, we systematically investigated the profile and role of m<sup>6</sup>A during spermatogenesis in pigs. By analyzing the transcriptomic distribution of m<sup>6</sup>A in spermatogonia, spermatocytes, and round spermatids, we identified a globally conserved m<sup>6</sup>A pattern bet","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-29T11:32:02.122Z","creation":"2025-04-06T19:54:11.995Z"},"accession":"S-EPMC10787014","cross_references":{"pubmed":["34543723"],"doi":["10.1016/j.gpb.2021.08.006"]}}