{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Le Franc L"],"funding":["CNRS","Ecosphère Continentale et Côtière ’HERITAGe’","Guillaume Rivière and the Council of the Normandy Region"],"pagination":["742-755"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10787124"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(4)"],"pubmed_abstract":["The N<sup>6</sup>-methylation of RNA adenosines (N<sup>6</sup>-methyladenosine, m<sup>6</sup>A) is an important regulator of gene expression with critical implications in vertebrate and insect development. However, the developmental significance of epitranscriptomes in lophotrochozoan organisms remains unknown. Using methylated RNA immunoprecipitation sequencing (MeRIP-seq), we generated transcriptome-wide m<sup>6</sup>A-RNA methylomes covering the entire development of the oyster from oocytes to juveniles. Oyster RNA classes display specific m<sup>6</sup>A signatures, with messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) exhibiting distinct profiles and being highly methylated compared to transposable element (TE) transcripts. Epitranscriptomes are dynamic and correspond to the c"],"journal":["Genomics, proteomics & bioinformatics"],"pubmed_title":["m<sup>6</sup>A Profile Dynamics Indicates Regulation of Oyster Development by m<sup>6</sup>A-RNA Epitranscriptomes."],"pmcid":["PMC10787124"],"funding_grant_id":["2019-200919362L","18E01643-18P02383"],"pubmed_authors":["Riviere G","Le Franc L","Petton B","Favrel P"],"additional_accession":[]},"is_claimable":false,"name":"m<sup>6</sup>A Profile Dynamics Indicates Regulation of Oyster Development by m<sup>6</sup>A-RNA Epitranscriptomes.","description":"The N<sup>6</sup>-methylation of RNA adenosines (N<sup>6</sup>-methyladenosine, m<sup>6</sup>A) is an important regulator of gene expression with critical implications in vertebrate and insect development. However, the developmental significance of epitranscriptomes in lophotrochozoan organisms remains unknown. Using methylated RNA immunoprecipitation sequencing (MeRIP-seq), we generated transcriptome-wide m<sup>6</sup>A-RNA methylomes covering the entire development of the oyster from oocytes to juveniles. Oyster RNA classes display specific m<sup>6</sup>A signatures, with messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) exhibiting distinct profiles and being highly methylated compared to transposable element (TE) transcripts. Epitranscriptomes are dynamic and correspond to the c","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-07-03T03:21:38.661Z","creation":"2024-11-21T03:37:43.791Z"},"accession":"S-EPMC10787124","cross_references":{"pubmed":["36496129"],"doi":["10.1016/j.gpb.2022.12.002"]}}