{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chuang Y-M"],"funding":["NCATS NIH HHS","Howard Hughes Medical Institute","NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases"],"pagination":["e0225723"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10790699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Importance</h4>When a female mosquito takes a blood meal from a mammalian host, components of the blood meal can affect mosquito fitness and indirectly influence pathogen infectivity. We identified a pathway involving an <i>Anopheles gambiae</i> adiponectin receptor, which, triggered by adiponectin from an incoming blood meal, decreases <i>Plasmodium</i> infection in the mosquito. Activation of this pathway negatively regulates lipophorin expression, an important lipid transporter that both enhances egg development and <i>Plasmodium</i> infection. This is an unrecognized cross-phyla interaction between a mosquito and its vertebrate host. These processes are critical to understanding the complex life cycle of mosquitoes and <i>Plasmodium</i> following a blood meal and may be applicable "],"journal":["mBio"],"pubmed_title":["Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces <i>Plasmodium</i> transmission."],"pmcid":["PMC10790699"],"funding_grant_id":["R01 AI158615","R21 AI142708","Emerging Pathogens Program","R01AI158615-01, R21AI142708, R41AI142708","UL1 TR001863"],"pubmed_authors":["Abouneameh S","Fikrig E","Stone H","Chuang Y-M","Tang X"],"additional_accession":[]},"is_claimable":false,"name":"Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces <i>Plasmodium</i> transmission.","description":"<h4>Importance</h4>When a female mosquito takes a blood meal from a mammalian host, components of the blood meal can affect mosquito fitness and indirectly influence pathogen infectivity. We identified a pathway involving an <i>Anopheles gambiae</i> adiponectin receptor, which, triggered by adiponectin from an incoming blood meal, decreases <i>Plasmodium</i> infection in the mosquito. Activation of this pathway negatively regulates lipophorin expression, an important lipid transporter that both enhances egg development and <i>Plasmodium</i> infection. This is an unrecognized cross-phyla interaction between a mosquito and its vertebrate host. These processes are critical to understanding the complex life cycle of mosquitoes and <i>Plasmodium</i> following a blood meal and may be applicable ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-02T09:07:36.431Z","creation":"2025-02-19T04:59:22.885Z"},"accession":"S-EPMC10790699","cross_references":{"pubmed":["38078744"],"doi":["10.1128/mbio.02257-23"]}}