biostudies-literatureChuang Y-MNCATS NIH HHSHoward Hughes Medical InstituteNIAID NIH HHSHHS | NIH | National Institute of Allergy and Infectious Diseasese0225723https://www.ebi.ac.uk/biostudies/studies/S-EPMC10790699biostudies-literatureUnknown15(1)<h4>Importance</h4>When a female mosquito takes a blood meal from a mammalian host, components of the blood meal can affect mosquito fitness and indirectly influence pathogen infectivity. We identified a pathway involving an <i>Anopheles gambiae</i> adiponectin receptor, which, triggered by adiponectin from an incoming blood meal, decreases <i>Plasmodium</i> infection in the mosquito. Activation of this pathway negatively regulates lipophorin expression, an important lipid transporter that both enhances egg development and <i>Plasmodium</i> infection. This is an unrecognized cross-phyla interaction between a mosquito and its vertebrate host. These processes are critical to understanding the complex life cycle of mosquitoes and <i>Plasmodium</i> following a blood meal and may be applicable mBioSignaling between mammalian adiponectin and a mosquito adiponectin receptor reduces <i>Plasmodium</i> transmission.PMC10790699R01 AI158615R21 AI142708Emerging Pathogens ProgramR01AI158615-01, R21AI142708, R41AI142708UL1 TR001863Abouneameh SFikrig EStone HChuang Y-MTang XfalseSignaling between mammalian adiponectin and a mosquito adiponectin receptor reduces <i>Plasmodium</i> transmission.<h4>Importance</h4>When a female mosquito takes a blood meal from a mammalian host, components of the blood meal can affect mosquito fitness and indirectly influence pathogen infectivity. We identified a pathway involving an <i>Anopheles gambiae</i> adiponectin receptor, which, triggered by adiponectin from an incoming blood meal, decreases <i>Plasmodium</i> infection in the mosquito. Activation of this pathway negatively regulates lipophorin expression, an important lipid transporter that both enhances egg development and <i>Plasmodium</i> infection. This is an unrecognized cross-phyla interaction between a mosquito and its vertebrate host. These processes are critical to understanding the complex life cycle of mosquitoes and <i>Plasmodium</i> following a blood meal and may be applicable 2024-01-01T00:00:00Z2024 Jan2026-06-02T09:07:36.431Z2025-02-19T04:59:22.885ZS-EPMC107906993807874410.1128/mbio.02257-23