biostudies-literatureUnknown45(2)Bovenzi R<h4>Introduction</h4>Safinamide is a recent antiparkinsonian drug that modulates both dopaminergic and glutamatergic systems with positive effects on motor and nonmotor symptoms of Parkinson's disease (PD). Here, we aimed to describe the efficacy and safety of safinamide in the Italian PD patients in real-life conditions.<h4>Methods</h4>We performed a sub-analysis of the Italian cohort of the SYNAPSES study, a multi-country, multi-center, retrospective-prospective cohort observational study, designed to investigate the use of safinamide in routine clinical practice. Patients received for the first time a treatment with safinamide and were followed up for 12 months. The analysis was conducted on the overall population and in subgroups of interest: i) patients > 75 years, ii) patients with rNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology573-583https://www.ebi.ac.uk/biostudies/studies/S-EPMC10791801biostudies-literatureReal-world use of Safinamide in motor fluctuating Parkinson's disease patients in Italy.PMC10791801Priori AMonge AColosimo CAguggia MCalabresi PMauri MCannas AAbbruzzese GContardi SEleopra RCortelli PPontieri FECanesi MGasparoli ESYNAPSES Study Investigators Italian GroupBarone PDi Lazzaro VBentivoglio ARFabbrini GZappia MDe Pandis MFPadovani ABovenzi RD'Amelio MCallegarini CTinazzi MNegrotti AMoleri MCossu GZambito Marsala SCentonze DMorgante FPacchetti CVitale CManganotti PProvinciali LLopiano LLiguori COnofrj MVolonte MAAvarello TNordera GComi CQuatrale RIliceto GMarini CGuidi MSpagnolo FCeravolo RMarconi RTessitore AStefani ASensi MBosco DTamma FfalseReal-world use of Safinamide in motor fluctuating Parkinson's disease patients in Italy.<h4>Introduction</h4>Safinamide is a recent antiparkinsonian drug that modulates both dopaminergic and glutamatergic systems with positive effects on motor and nonmotor symptoms of Parkinson's disease (PD). Here, we aimed to describe the efficacy and safety of safinamide in the Italian PD patients in real-life conditions.<h4>Methods</h4>We performed a sub-analysis of the Italian cohort of the SYNAPSES study, a multi-country, multi-center, retrospective-prospective cohort observational study, designed to investigate the use of safinamide in routine clinical practice. Patients received for the first time a treatment with safinamide and were followed up for 12 months. The analysis was conducted on the overall population and in subgroups of interest: i) patients > 75 years, ii) patients with r2024-01-01T00:00:00Z2024 Feb2025-04-19T00:58:28.264Z2025-04-07T11:55:40.026ZS-EPMC107918013768451110.1007/s10072-023-07001-6