biostudies-literatureDe Clercq JFonds Wetenschappelijk OnderzoekUniversiteit GentViiV Healthcare1337316https://www.ebi.ac.uk/biostudies/studies/S-EPMC10796502biostudies-literatureUnknown14<h4>Background</h4>Despite the beneficial effects of antiretroviral therapy (ART) initiation during acute HIV infection (AHI), residual immune activation remains a hallmark of treated HIV infection.<h4>Methods</h4>Plasma concentrations of 40 mediators were measured longitudinally in 39 early treated participants of a Belgian AHI cohort (HIV+) and in 21 HIV-negative controls (HIV-). We investigated the association of the inflammatory profile with clinical presentation, plasma viral load, immunological parameters, and in-depth characterization of the HIV reservoir.<h4>Results</h4>While levels of most soluble mediators normalized with suppressive ART, we demonstrated the persistence of a pro-inflammatory signature in early treated HIV+ participants in comparison to HIV- controls. Examination Frontiers in immunologyLongitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir.PMC10796502BOF19/DOC/220, BOF.DOC.2019.0068.02)1.8.020.09.N.00De Scheerder MAVerhofstede CVandecasteele SJAllard SDGerlo SVandekerckhove LDe Clercq JNecsoi CDe Wit SMortier VfalseLongitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir.<h4>Background</h4>Despite the beneficial effects of antiretroviral therapy (ART) initiation during acute HIV infection (AHI), residual immune activation remains a hallmark of treated HIV infection.<h4>Methods</h4>Plasma concentrations of 40 mediators were measured longitudinally in 39 early treated participants of a Belgian AHI cohort (HIV+) and in 21 HIV-negative controls (HIV-). We investigated the association of the inflammatory profile with clinical presentation, plasma viral load, immunological parameters, and in-depth characterization of the HIV reservoir.<h4>Results</h4>While levels of most soluble mediators normalized with suppressive ART, we demonstrated the persistence of a pro-inflammatory signature in early treated HIV+ participants in comparison to HIV- controls. Examination 2023-01-01T00:00:00Z20232026-06-02T02:23:20.641Z2025-04-04T19:21:51.485ZS-EPMC107965023825008310.3389/fimmu.2023.1337316