biostudies-literatureUnknown14(1)Loscocco GGWe describe 1000 patients with essential thrombocythemia seen at the Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Florence, Italy, between 1980 and 2023: median age 59 years (18-95), females 65%, JAK2/CALR/MPL-mutated 66%/19%/4%, triple-negative (TN) 11%. Extreme thrombocytosis (ExT, platelets ≥1000 × 10⁹/L) in 16%, leukocytosis (leukocytes >11 × 10⁹/L) in 16%, and at least one cardiovascular risk factor in 52% of cases. JAK2-mutated patients were older (median 62 years) and CALR-mutated and TN (53 years for both) younger (p < 0.001). Female gender clustered with TN (76%) and JAK2 (67%) vs CALR (46%) mutations (p < 0.001). ExT clustered with CALR (type-2 more than type-1), TN and MPL, and leukocytosis with JAK2 mutation (p < 0.001). In multiBlood cancer journal10https://www.ebi.ac.uk/biostudies/studies/S-EPMC10796728biostudies-literatureOne thousand patients with essential thrombocythemia: the Florence-CRIMM experience.PMC10796728Loscocco GGVannucchi AMCapecchi GGuglielmelli PAtanasio AMaccari CGesullo FMannelli FfalseOne thousand patients with essential thrombocythemia: the Florence-CRIMM experience.We describe 1000 patients with essential thrombocythemia seen at the Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Florence, Italy, between 1980 and 2023: median age 59 years (18-95), females 65%, JAK2/CALR/MPL-mutated 66%/19%/4%, triple-negative (TN) 11%. Extreme thrombocytosis (ExT, platelets ≥1000 × 10⁹/L) in 16%, leukocytosis (leukocytes >11 × 10⁹/L) in 16%, and at least one cardiovascular risk factor in 52% of cases. JAK2-mutated patients were older (median 62 years) and CALR-mutated and TN (53 years for both) younger (p < 0.001). Female gender clustered with TN (76%) and JAK2 (67%) vs CALR (46%) mutations (p < 0.001). ExT clustered with CALR (type-2 more than type-1), TN and MPL, and leukocytosis with JAK2 mutation (p < 0.001). In multi2024-01-01T00:00:00Z2024 Jan2025-04-04T10:34:33.777Z2025-04-04T10:34:33.777ZS-EPMC107967283823828710.1038/s41408-023-00968-7