{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang S"],"funding":["Natural Science Foundation of Shandong Province","Jining Medical University","China Postdoctoral Science Foundation","National Natural Science Foundation of China"],"pagination":["e23833"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10797151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Betulinic acid (BA) is a pentacyclic triterpene found in many plant species and has a broad-spectrum anti-tumor effect in various cancers, including colon cancer (CRC). However, its anticancer mechanism in CRC is no clear. RNA sequencing and bioinformatics analysis showed BA up-regulated 378 genes and down-regulated 137 genes in HT29 cells, while 2303 up-regulated and 1041 down-regulated genes were found in SW480 cells. KEGG enrichment analysis showed BA significantly stimulated the expression of metallothionein 1 (MT1) family genes in both HT29 and SW480 cells. Metallothionein 1G (MT1G) was the gene with the highest upregulation of MT1 family genes induced by BA dose-dependently. High MT1G expression enhanced the sensitivity of CRC cells to BA, whereas, MT1G knockdown had the opposite eff"],"journal":["Heliyon"],"pubmed_title":["Betulinic acid arrests cell cycle at G2/M phase by up-regulating metallothionein 1G inhibiting proliferation of colon cancer cells."],"pmcid":["PMC10797151"],"funding_grant_id":["2020-BS006","ZR2020YQ59","JYHL2019FMS05","2022M721339","82102798,82173371,82273447,82273069,82372679","ZR2019BH050"],"pubmed_authors":["Yang X","Wang S","Zhang Y","Bie Q","Zhang B","Wang K"],"additional_accession":[]},"is_claimable":false,"name":"Betulinic acid arrests cell cycle at G2/M phase by up-regulating metallothionein 1G inhibiting proliferation of colon cancer cells.","description":"Betulinic acid (BA) is a pentacyclic triterpene found in many plant species and has a broad-spectrum anti-tumor effect in various cancers, including colon cancer (CRC). However, its anticancer mechanism in CRC is no clear. RNA sequencing and bioinformatics analysis showed BA up-regulated 378 genes and down-regulated 137 genes in HT29 cells, while 2303 up-regulated and 1041 down-regulated genes were found in SW480 cells. KEGG enrichment analysis showed BA significantly stimulated the expression of metallothionein 1 (MT1) family genes in both HT29 and SW480 cells. Metallothionein 1G (MT1G) was the gene with the highest upregulation of MT1 family genes induced by BA dose-dependently. High MT1G expression enhanced the sensitivity of CRC cells to BA, whereas, MT1G knockdown had the opposite eff","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-07-15T04:43:30.419Z","creation":"2025-04-04T10:38:28.502Z"},"accession":"S-EPMC10797151","cross_references":{"pubmed":["38261922"],"doi":["10.1016/j.heliyon.2023.e23833"]}}