{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chai Y"],"funding":["The 16th Six Talent Peaks Project of Jiangsu Province","National Natural Science Foundation of China","\"Double First Class\" University Project","The Jiangsu Funding Program for Excellent Postdoctoral Talent"],"pagination":["e2304994"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10797437"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(3)"],"pubmed_abstract":["Atherosclerosis is a chronic inflammatory disease that affects arteries and is the main cause of cardiovascular disease. Atherosclerotic plaque formation is usually asymptomatic and does not manifest until the occurrence of clinical events. Therefore, early diagnosis and treatment of atherosclerotic plaques is particularly important. Here, a series of NIR-II fluorescent dyes (RBT-NH) are developed for three photoresponsive NO prodrugs (RBT-NO), which can be controllably triggered by 808 nm laser to release NO and turn on the NIR-II emission in the clinical medicine \"therapeutic window\". Notably, RBT3-NO is selected for its exhibited high NO releasing efficiency and superior fluorescence signal enhancement. Subsequently, a platelet-mimicking nano-prodrug system (RBT3-NO-PEG@PM) is construct"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics."],"pmcid":["PMC10797437"],"funding_grant_id":["CPUQNJC22-03","82272148","2022ZB301","SWYY-063"],"pubmed_authors":["Liu Y","Shangguan L","Zhu Y","Huang X","Chai Y","Sun Y","Yu H","Wang HY"],"additional_accession":[]},"is_claimable":false,"name":"Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics.","description":"Atherosclerosis is a chronic inflammatory disease that affects arteries and is the main cause of cardiovascular disease. Atherosclerotic plaque formation is usually asymptomatic and does not manifest until the occurrence of clinical events. Therefore, early diagnosis and treatment of atherosclerotic plaques is particularly important. Here, a series of NIR-II fluorescent dyes (RBT-NH) are developed for three photoresponsive NO prodrugs (RBT-NO), which can be controllably triggered by 808 nm laser to release NO and turn on the NIR-II emission in the clinical medicine \"therapeutic window\". Notably, RBT3-NO is selected for its exhibited high NO releasing efficiency and superior fluorescence signal enhancement. Subsequently, a platelet-mimicking nano-prodrug system (RBT3-NO-PEG@PM) is construct","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-04T19:21:43.725Z","creation":"2025-04-04T19:21:43.725Z"},"accession":"S-EPMC10797437","cross_references":{"pubmed":["38037484"],"doi":["10.1002/advs.202304994"]}}