{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(2)"],"submitter":["Sciandrone B"],"pubmed_abstract":["Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder characterized by ataxia and other neurological manifestations, with a poor prognosis and a lack of effective therapies. The amyloid aggregation of the ataxin-3 protein is a hallmark of SCA3 and one of the main biochemical events prompting its onset, making it a prominent target for the development of preventive and therapeutic interventions. Here, we tested the efficacy of an aqueous <i>Lavado</i> cocoa extract and its polyphenolic components against ataxin-3 aggregation and neurotoxicity. The combination of biochemical assays and atomic force microscopy morphological analysis provided clear evidence of cocoa flavanols' ability to hinder ATX3 amyloid aggregation through direct physical interaction, as assessed by NMR spec"],"journal":["ACS chemical neuroscience"],"pagination":["278-289"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10797631"],"repository":["biostudies-literature"],"pubmed_title":["Cell-Free and In Vivo Characterization of the Inhibitory Activity of <i>Lavado</i> Cocoa Flavanols on the Amyloid Protein Ataxin-3: Toward New Approaches against Spinocerebellar Ataxia Type 3."],"pmcid":["PMC10797631"],"pubmed_authors":["Regonesi ME","Colombo L","Airoldi C","Palmioli A","Pensotti R","Ciaramelli C","Sciandrone B"],"additional_accession":[]},"is_claimable":false,"name":"Cell-Free and In Vivo Characterization of the Inhibitory Activity of <i>Lavado</i> Cocoa Flavanols on the Amyloid Protein Ataxin-3: Toward New Approaches against Spinocerebellar Ataxia Type 3.","description":"Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder characterized by ataxia and other neurological manifestations, with a poor prognosis and a lack of effective therapies. The amyloid aggregation of the ataxin-3 protein is a hallmark of SCA3 and one of the main biochemical events prompting its onset, making it a prominent target for the development of preventive and therapeutic interventions. Here, we tested the efficacy of an aqueous <i>Lavado</i> cocoa extract and its polyphenolic components against ataxin-3 aggregation and neurotoxicity. The combination of biochemical assays and atomic force microscopy morphological analysis provided clear evidence of cocoa flavanols' ability to hinder ATX3 amyloid aggregation through direct physical interaction, as assessed by NMR spec","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2025-04-04T10:34:23.719Z","creation":"2025-04-04T10:34:23.719Z"},"accession":"S-EPMC10797631","cross_references":{"pubmed":["38154144"],"doi":["10.1021/acschemneuro.3c00560"]}}