biostudies-literatureYao WNatural Science Foundation of Hebei ProvinceNational Natural Science Foundation of China34https://www.ebi.ac.uk/biostudies/studies/S-EPMC10797997biostudies-literatureUnknown22(1)Severe tissue injuries pose a significant risk to human health. Conventional wound dressings fall short in achieving effective tissue regeneration, resulting in suboptimal postoperative healing outcomes. In this study, an asymmetric adhesive wound dressing (marked as SIS/PAA/LAP) was developed, originating from acrylate acid (AA) solution with laponite (LAP) nanoparticles polymerization and photo-crosslinked on the decellularized extracellular matrix small intestinal submucosa (SIS) patch. Extensive studies demonstrated that the SIS/PAA/LAP exhibited higher tissue adhesion strength (~ 33 kPa) and burst strength (~ 22 kPa) compared to conventional wound dressings like Tegaderm and tissue adhesive products. Importantly, it maintained favorable cell viability and demonstrated robust angiogeniJournal of nanobiotechnologyAsymmetric adhesive SIS-based wound dressings for therapeutically targeting wound repair.PMC10797997H202050500782102342Zhang JZhao BMa XHan YYao WJing WLi YWei PHuang YZhang XXiong CYang SSong ZXu YfalseAsymmetric adhesive SIS-based wound dressings for therapeutically targeting wound repair.Severe tissue injuries pose a significant risk to human health. Conventional wound dressings fall short in achieving effective tissue regeneration, resulting in suboptimal postoperative healing outcomes. In this study, an asymmetric adhesive wound dressing (marked as SIS/PAA/LAP) was developed, originating from acrylate acid (AA) solution with laponite (LAP) nanoparticles polymerization and photo-crosslinked on the decellularized extracellular matrix small intestinal submucosa (SIS) patch. Extensive studies demonstrated that the SIS/PAA/LAP exhibited higher tissue adhesion strength (~ 33 kPa) and burst strength (~ 22 kPa) compared to conventional wound dressings like Tegaderm and tissue adhesive products. Importantly, it maintained favorable cell viability and demonstrated robust angiogeni2024-01-01T00:00:00Z2024 Jan2026-03-27T16:37:05.363Z2025-04-04T19:21:56.637ZS-EPMC107979973823874810.1186/s12951-024-02294-x