{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clifford RE"],"funding":["BLRD VA","RRD VA","U.S. Department of Veterans Affairs","CSRD VA"],"pagination":["614"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10799010"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical specialties. Previous GWAS indicated high genetic correlations between tinnitus and hearing loss, with little indication of differentiating signals. We present a GWAS meta-analysis, triple previous sample sizes, and expand to non-European ancestries. GWAS in 596,905 Million Veteran Program subjects identified 39 tinnitus loci, and identified genes related to neuronal synapses and cochlear structural support. Applying state-of-the-art analytic tools, we confirm a large number of shared variants, but also a distinct genetic architecture of tinnitus, with higher polygenicity and large proportion of variants not shared with hearing difficulty. Tissue-expression analysis for tinnitus infers broad enrichment "],"journal":["Nature communications"],"pubmed_title":["Genetic architecture distinguishes tinnitus from hearing loss."],"pmcid":["PMC10799010"],"funding_grant_id":["I01 BX005920","RX004293","I01 RX004293","IK2 CX002107","I01 RX002744","I01 BX001205","BX005920"],"pubmed_authors":["Stein MB","Coleman JRI","Daskalakis NP","Zuo Y","Telese F","Clifford RE","Maihofer AX","Gasperi M","Nievergelt CM","Chatzinakos C","Mikita EA","Ryan AF","Tcheandjieu C","Hogan K"],"additional_accession":[]},"is_claimable":false,"name":"Genetic architecture distinguishes tinnitus from hearing loss.","description":"Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical specialties. Previous GWAS indicated high genetic correlations between tinnitus and hearing loss, with little indication of differentiating signals. We present a GWAS meta-analysis, triple previous sample sizes, and expand to non-European ancestries. GWAS in 596,905 Million Veteran Program subjects identified 39 tinnitus loci, and identified genes related to neuronal synapses and cochlear structural support. Applying state-of-the-art analytic tools, we confirm a large number of shared variants, but also a distinct genetic architecture of tinnitus, with higher polygenicity and large proportion of variants not shared with hearing difficulty. Tissue-expression analysis for tinnitus infers broad enrichment ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-02T06:52:14.128Z","creation":"2025-04-04T19:22:13.942Z"},"accession":"S-EPMC10799010","cross_references":{"pubmed":["38242899"],"doi":["10.1038/s41467-024-44842-x"]}}