{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morales-Munoz I"],"funding":["Academy of Finland","Finnish Cultural Foundation","Arvo ja Lea Ylppö Foundation","Yrjö Jahnsson Foundation","Foundation for Pediatric Research","Signe and Ane Gyllenberg foundation"],"pagination":["zsad047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10799321"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(7)"],"pubmed_abstract":["<h4>Study objectives</h4>We studied the associations between polygenic risk score (PRS) for attention deficit and hyperactivity disorder (ADHD) and (1) ADHD symptoms in 5-year-old children, (2) sleep duration throughout childhood, and (3) the interaction between PRS for ADHD and short sleep duration relative to ADHD symptoms at 5 years.<h4>Methods</h4>This study is based on the population-based CHILD-SLEEP birth cohort (N = 1420 children). PRS was used to quantitate the genetic risk for ADHD. Parent-reported ADHD symptoms at 5 years were obtained from 714 children, using the Strengths and Difficulties Questionnaire (SDQ) and the Five-to-Fifteen (FTF). Our primary outcomes were SDQ-hyperactivity and FTF-ADHD total scores. Parent-reported sleep duration was measured at 3, 8, 18, 24 months, a"],"journal":["Sleep"],"pubmed_title":["Genetic background to attention deficit and hyperactivity disorder and attention deficit and hyperactivity disorder symptoms at the age of 5 years: the role of sleep duration."],"pmcid":["PMC10799321"],"funding_grant_id":["#308588","#315035","#277557","#253346","#342747","#326631","#134880"],"pubmed_authors":["Saarenpaa-Heikkila O","Morales-Munoz I","Paunio T","Kylliainen A","Harkanen T","Paavonen EJ","Kantojarvi K","Himanen SL"],"additional_accession":[]},"is_claimable":false,"name":"Genetic background to attention deficit and hyperactivity disorder and attention deficit and hyperactivity disorder symptoms at the age of 5 years: the role of sleep duration.","description":"<h4>Study objectives</h4>We studied the associations between polygenic risk score (PRS) for attention deficit and hyperactivity disorder (ADHD) and (1) ADHD symptoms in 5-year-old children, (2) sleep duration throughout childhood, and (3) the interaction between PRS for ADHD and short sleep duration relative to ADHD symptoms at 5 years.<h4>Methods</h4>This study is based on the population-based CHILD-SLEEP birth cohort (N = 1420 children). PRS was used to quantitate the genetic risk for ADHD. Parent-reported ADHD symptoms at 5 years were obtained from 714 children, using the Strengths and Difficulties Questionnaire (SDQ) and the Five-to-Fifteen (FTF). Our primary outcomes were SDQ-hyperactivity and FTF-ADHD total scores. Parent-reported sleep duration was measured at 3, 8, 18, 24 months, a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-04T14:16:19.467Z","creation":"2025-04-04T14:16:19.467Z"},"accession":"S-EPMC10799321","cross_references":{"pubmed":["36861221"],"doi":["10.1093/sleep/zsad047"]}}