biostudies-literatureMorales-Munoz IAcademy of FinlandFinnish Cultural FoundationArvo ja Lea Ylppö FoundationYrjö Jahnsson FoundationFoundation for Pediatric ResearchSigne and Ane Gyllenberg foundationzsad047https://www.ebi.ac.uk/biostudies/studies/S-EPMC10799321biostudies-literatureUnknown46(7)<h4>Study objectives</h4>We studied the associations between polygenic risk score (PRS) for attention deficit and hyperactivity disorder (ADHD) and (1) ADHD symptoms in 5-year-old children, (2) sleep duration throughout childhood, and (3) the interaction between PRS for ADHD and short sleep duration relative to ADHD symptoms at 5 years.<h4>Methods</h4>This study is based on the population-based CHILD-SLEEP birth cohort (N = 1420 children). PRS was used to quantitate the genetic risk for ADHD. Parent-reported ADHD symptoms at 5 years were obtained from 714 children, using the Strengths and Difficulties Questionnaire (SDQ) and the Five-to-Fifteen (FTF). Our primary outcomes were SDQ-hyperactivity and FTF-ADHD total scores. Parent-reported sleep duration was measured at 3, 8, 18, 24 months, aSleepGenetic background to attention deficit and hyperactivity disorder and attention deficit and hyperactivity disorder symptoms at the age of 5 years: the role of sleep duration.PMC10799321#308588#315035#277557#253346#342747#326631#134880Saarenpaa-Heikkila OMorales-Munoz IPaunio TKylliainen AHarkanen TPaavonen EJKantojarvi KHimanen SLfalseGenetic background to attention deficit and hyperactivity disorder and attention deficit and hyperactivity disorder symptoms at the age of 5 years: the role of sleep duration.<h4>Study objectives</h4>We studied the associations between polygenic risk score (PRS) for attention deficit and hyperactivity disorder (ADHD) and (1) ADHD symptoms in 5-year-old children, (2) sleep duration throughout childhood, and (3) the interaction between PRS for ADHD and short sleep duration relative to ADHD symptoms at 5 years.<h4>Methods</h4>This study is based on the population-based CHILD-SLEEP birth cohort (N = 1420 children). PRS was used to quantitate the genetic risk for ADHD. Parent-reported ADHD symptoms at 5 years were obtained from 714 children, using the Strengths and Difficulties Questionnaire (SDQ) and the Five-to-Fifteen (FTF). Our primary outcomes were SDQ-hyperactivity and FTF-ADHD total scores. Parent-reported sleep duration was measured at 3, 8, 18, 24 months, a2023-01-01T00:00:00Z2023 Jul2025-04-04T14:16:19.467Z2025-04-04T14:16:19.467ZS-EPMC107993213686122110.1093/sleep/zsad047