{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Jadon N"],"funding":["U.S. Department of Defense"],"pubmed_abstract":["<h4>Background</h4>Induced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1)-like iTregs. Thus, it is important to distinguish between functional plasticity and lineage instability. Aplastic anemia (AA) is an autoimmune disorder characterized by immune-mediated destruction of hematopoietic stem and progenitor cells in the bone marrow (BM). Th1-like 1 iTregs can be potent suppressors of aberrant Th1-mediated immune responses such as those that drive AA disease progression. Here we investigated the function of the epigenetic enzyme, protein arginine methyltransferase 5 (PRMT5), its regulation of the iTreg-desta"],"journal":["Frontiers in immunology"],"pagination":["1292049"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10800960"],"repository":["biostudies-literature"],"pubmed_title":["PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment."],"pmcid":["PMC10800960"],"pubmed_authors":["Jadon N","Minter LM","Shanthalingam S","Tew GN"],"additional_accession":[]},"is_claimable":false,"name":"PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.","description":"<h4>Background</h4>Induced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1)-like iTregs. Thus, it is important to distinguish between functional plasticity and lineage instability. Aplastic anemia (AA) is an autoimmune disorder characterized by immune-mediated destruction of hematopoietic stem and progenitor cells in the bone marrow (BM). Th1-like 1 iTregs can be potent suppressors of aberrant Th1-mediated immune responses such as those that drive AA disease progression. Here we investigated the function of the epigenetic enzyme, protein arginine methyltransferase 5 (PRMT5), its regulation of the iTreg-desta","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-07-15T10:03:59.133Z","creation":"2024-11-20T13:19:58.984Z"},"accession":"S-EPMC10800960","cross_references":{"pubmed":["38259494"],"doi":["10.3389/fimmu.2023.1292049"]}}