biostudies-literatureUnknown14Jadon NU.S. Department of Defense<h4>Background</h4>Induced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1)-like iTregs. Thus, it is important to distinguish between functional plasticity and lineage instability. Aplastic anemia (AA) is an autoimmune disorder characterized by immune-mediated destruction of hematopoietic stem and progenitor cells in the bone marrow (BM). Th1-like 1 iTregs can be potent suppressors of aberrant Th1-mediated immune responses such as those that drive AA disease progression. Here we investigated the function of the epigenetic enzyme, protein arginine methyltransferase 5 (PRMT5), its regulation of the iTreg-destaFrontiers in immunology1292049https://www.ebi.ac.uk/biostudies/studies/S-EPMC10800960biostudies-literaturePRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.PMC10800960Jadon NMinter LMShanthalingam STew GNfalsePRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.<h4>Background</h4>Induced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1)-like iTregs. Thus, it is important to distinguish between functional plasticity and lineage instability. Aplastic anemia (AA) is an autoimmune disorder characterized by immune-mediated destruction of hematopoietic stem and progenitor cells in the bone marrow (BM). Th1-like 1 iTregs can be potent suppressors of aberrant Th1-mediated immune responses such as those that drive AA disease progression. Here we investigated the function of the epigenetic enzyme, protein arginine methyltransferase 5 (PRMT5), its regulation of the iTreg-desta2023-01-01T00:00:00Z20232026-07-15T10:03:59.133Z2024-11-20T13:19:58.984ZS-EPMC108009603825949410.3389/fimmu.2023.1292049