{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garcia-Lopez MA"],"funding":["Ministerio de Ciencia e Innovación (MCIN)","Fundación BBVA","Comunidad de Madrid","Ministerio de Ciencia e Innovación","Fundación BBVA (FBBVA)","Comunidad de Madrid (Community of Madrid)"],"pagination":["e2300096121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10801893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(3)"],"pubmed_abstract":["The prevalence of overweight and obesity continues to rise in the population worldwide. Because it is an important predisposing factor for cancer, cardiovascular diseases, diabetes mellitus, and COVID-19, obesity reduces life expectancy. Adipose tissue (AT), the main fat storage organ with endocrine capacity, plays fundamental roles in systemic metabolism and obesity-related diseases. Dysfunctional AT can induce excess or reduced body fat (lipodystrophy). <i>Dido1</i> is a marker gene for stemness; gene-targeting experiments compromised several functions ranging from cell division to embryonic stem cell differentiation, both in vivo and in vitro. We report that mutant mice lacking the DIDO N terminus show a lean phenotype. This consists of reduced AT and hypolipidemia, even when mice are f"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["DIDO is necessary for the adipogenesis that promotes diet-induced obesity."],"pmcid":["PMC10801893"],"funding_grant_id":["S2017/BMD-3804","PID2022-142616OB-100","&quot;The role of Dido...&quot;","PID2019-110574RB-100","\"The role of Dido...\""],"pubmed_authors":["Sabio G","Fischer T","Mora A","Sanchez de Diego A","Talavera Gutierrez A","Garcia-Lopez MA","Medina-Gomez G","Pons T","Martinez-A C","Corrales P","van Wely KHM"],"additional_accession":[]},"is_claimable":false,"name":"DIDO is necessary for the adipogenesis that promotes diet-induced obesity.","description":"The prevalence of overweight and obesity continues to rise in the population worldwide. Because it is an important predisposing factor for cancer, cardiovascular diseases, diabetes mellitus, and COVID-19, obesity reduces life expectancy. Adipose tissue (AT), the main fat storage organ with endocrine capacity, plays fundamental roles in systemic metabolism and obesity-related diseases. Dysfunctional AT can induce excess or reduced body fat (lipodystrophy). <i>Dido1</i> is a marker gene for stemness; gene-targeting experiments compromised several functions ranging from cell division to embryonic stem cell differentiation, both in vivo and in vitro. We report that mutant mice lacking the DIDO N terminus show a lean phenotype. This consists of reduced AT and hypolipidemia, even when mice are f","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-07-15T05:14:47.169Z","creation":"2025-04-04T11:24:42.732Z"},"accession":"S-EPMC10801893","cross_references":{"pubmed":["38194457"],"doi":["10.1073/pnas.2300096121"]}}